Regional differences in adipose tissue metabolism between sedentary
and endurance-trained women.
Mauri[grave]ege, P., D. Prud'homme, M. Marcotte, M. Yoshioka, A.
Tremblay, and J. P. Despr[acute]es.
Physical Activity Sciences Laboratory, Laval University, Lipid
Research Center, CHUL Medical Research Center, Ste-Foy,
Qu[acute]ebec, Canada
APStracts 4:0110E, 1997.
Subcutaneous (subc) abdominal and femoral adipose tissue metabolism
was studied in sedentary and endurance-trained premenopausal women.
Both fat cell weight and lipoprotein lipase (LPL) activity were lower
in the subc abdominal depot of trained women compared to controls.
Epinephrine- and isoproterenol-stimulated lipolytic responses as well
as the [beta]-adrenergic sensitivity of subc abdominal adipocytes
were higher in trained than in sedentary women, whereas both the
antilipolytic effect of UK14304 and the [alpha]2-adrenoceptor
sensitivity were lower in endurance-trained than in sedentary
subjects. Maximal lipolysis in the presence of post-adrenoceptor
agents was also enhanced in subc abdominal adipose cells of trained
women compared to sedentary controls. Negative relationships were
found between maximal lipolytic responses of subc abdominal fat cells
to catecholamines or to post-receptor agents and body fatness as well
as abdominal fat distribution indices. It is concluded that 1)
endurance-trained women are characterized by a preferential lipid
mobilization from the subc abdominal fat depot, 2) differences in the
metabolic characteristics of subc abdominal adipocytes between
trained and sedentary women may involve changes in both LPL activity
and the lipolytic cascade which include modifications at receptor and
post-receptor levels. However, these alterations appear to be largely
resulting from the reduced adipose cell size rather than from
exercise-training per se.
Received 9 May 1996; accepted in final form 29 April 1997.
APS Manuscript Number E232-6.
Article publication pending Am. J. Physiol. (Endocrinol. Metab.).
ISSN 1080-4757 Copyright 1997 The American Physiological Society.
Published in APStracts on 11 June 1997