Prolonged submaximal eccentric exercise is associated with
increased levels of plasma il-6.
Rohde, Thomas, Dave A. Maclean, Erik A. Richter, Bente Kiens, and
Bente Klarlund Pedersen.
The Copenhagen Muscle Research Centre, Department of Infectious
Diseases, Rigshospitalet, University Hospital, Copenhagen and August
Krogh Institute, University of Copenhagen, Denmark
APStracts 4:0066E, 1997.
To study the relationship between exercise-related muscle proteolysis
and the cytokine response, a prolonged one legged eccentric exercise
model was used. Subjects performed two trials (a branched chain amino
acid (BCAA) supplementation and a control trial). The release of
amino acids from muscle during and following the eccentric exercise
was decreased in the BCAA trial, suggesting a suppression of net
muscle protein degradation. The plasma concentrations of interleukin
(IL)-6 increased from 0.75+/-0.19 (pre-exercise) to 5.02+/-0.96 pg
ml-1 (2 hrs post-exercise) in the control trial and in the BCAA
supplementation trial from 1.07+/-0.41 to 4.15+/-1.21 pg ml-1.
Eccentric exercise had no effect on the concentrations of
neutrophils, lymphocytes, CD16+/CD56+, CD4+, CD8+, CD14+/CD38+,
lymphocyte proliferative response or cytotoxic activities. BCAA
supplementation reduced the concentration of CD14+/CD38+ cells. This
study shows that the concentration of IL-6 in plasma is increased
after prolonged eccentric exercise and suggests that the cytokine
response is independent of the muscle proteolysis that occur during
exercise.
Received 28 October 1996; accepted in final form 4 March 1997.
APS Manuscript Number E533-6.
Article publication pending Am. J. Physiol. (Endocrinol. Metab.).
ISSN 1080-4757 Copyright 1997 The American Physiological Society.
Published in APStracts on 21 March 1997