Food restriction alters pregnancy-associated changes in igf and
igfbp in the guinea pig..
Sohlstrom, Katsman, Kind K., Roberts C., Owens P., Robinson J. and
Owens J.
Department of Obstetrics and Gynaecology and 3Department of
Physiology, University of Adelaide, South Australia 5005, Australia.
Department of Physiology and Pharmacology, Karolinska Institutet, S
-171 77 Stockholm, Sweden. Division of Human Nutrition, C. S. I. R.
O., P. O. Box 10041, Gouger Street, Adelaide, South Australia 5000,
Australia.
APStracts 4:0249E, 1997.
The effect of moderate food restriction on pregnancy-associated
changes in weight gain, body composition and circulating IGF-I, IGF
-II and IGFBP 1-4 and their relationship was determined in the guinea
pig. Pregnancy did not stimulate weight gain, but reduced fat
deposition in ad libitum fed animals, and increased weight gain and
fat deposition in food restricted animals, relative to their
respective virginal group. Pregnancy increased the abundance of
circulating IGF-I regardless of food intake, and increased that of
IGF-II in food restricted animals only. Pregnancy also increased
circulating IGFBP-1 and -2 in ad libitum fed and food restricted
animals and IGFBP-4 in ad libitum fed animals. Multiple regression
analysis showed that maternal weight gain was negatively associated
with circulating IGF-II and IGFBP-2. Fetal weight was positively
associated with maternal circulating IGF-II and negatively associated
with maternal circulating IGFBP-1 and -2. Significant interactions
indicate, however, that the role of IGF-II and IGFBP-1 on fetal
growth is dependent on the nutritional status of the mother.
Received 14 April 1997; accepted in final form 6 November 1997.
APS Manuscript Number E168-7.
Article publication pending Am. J. Physiol. (Endocrinol. Metab.).
ISSN 1080-4757 Copyright 1997 The American Physiological Society.
Published in APStracts on 14 November 1997