APStracts (ISSN 1080-4757) Vol. 4, 1997

The American Physiological Society

• Chronic carbachol pretreatment decreases adenylyl cyclase activity in airway smooth muscle. Schears, Gregory, Judy Clancy, Carol A. Hirshman, Charles W. Emala. Departments of Anesthesiology and Environmental Health Sciences, Johns Hopkins Medical Institutions APStracts 4:0139L, 1997.
• Interleukin-1[beta] alters beta adrenergic receptor - adenylyl cyclase ( [beta]ar-ac) system function in human airway epithelial cells. Kelsen, Steven G., Onyeama Anakwe, Mark O. Aksoy, P. J. Reddy, N. Dhanasekaran. Division of Pulmonary and Critical Care Medicine, Department of Medicine, and Fels Institute for Cancer Research and Molecular Biology, Temple University School of Medicine, Philadelphia, PA 19140 APStracts 4:0140L, 1997.
• Inhibiting formation of phosphatidic acid species containing oleate and linoleate produces an intrinsic resistance to oxidative injury in isolated rat lungs. Guidot, David M., Stuart L. Bursten, Glenn C. Rice, Robert B. Chaney, Jack W. Singer, Alexander J. Repine, Brooks M. Hybertson, John E. Repine. Webb-Waring Institute for Biomedical Research, University of Colorado Health Sciences Center, Denver, CO, Atlanta VAMC, Emory University Department of Medicine, Atlanta, GA, and Cell Therapeutics[cedilla]c, Inc., Seattle, WA. APStracts 4:0141L, 1997.
• Fibronectin and biosynthesized matrix but not collagen support bronchial epithelial cell attachment and survival in the absence of growth factors. Aoshiba, Kazutetsu, Stephen I. Rennard, John R. Spurzem, M. D. Research Service of the Department of Veterans Affairs, Medical Center, Omaha, NE 68105, Department of Internal Medicine, University of Nebraska, Medical Center, Omaha, NE 68198-5300 APStracts 4:0142L, 1997.
• Down-modulation of il-8 receptors type a and type b on human lung neutrophils in vivo. Soejima, Kenzo, Seitaro Fujishima, Hidetoshi Nakamura, Yasuhiro Waki, Morio Nakamura, Hiroaki Matsubara, Sadatomo Tasaka, Koichi Sayama, Akitoshi Ishizaka, Minoru Kanazawa. Department of Medicine, School of Medicine, Keio University APStracts 4:0143L, 1997.
• Increased expression of the interleukin 10 gene by alveolar macrophages in interstitial lung disease. Martinez, Jose A. Baddini, Talmadge E. King, Jr., Kevin Brown, Constance A. Jennings, Larry Borish, Rebecca L. Mortenson, Talat Z. Khan, Thomas W. Bost, and David W. H. Riches. Department of Pediatrics and Department of Medicine, National Jewish Medical and Research Center, Department of Biochemistry, Biophysics and Genetics, Division of Pulmonary Sciences, Department of Medicine and Department of Pharmacology, University of Colorado Health Sciences Center, Denver, CO. APStracts 4:0144L, 1997.
• Tgf-[beta] inhibits il-4-stimulated il-8 production, and il-4 inhibits tgf-[beta]- stimulated fibronectin production by cultured human bronchial epithelial cells. Adachi, Yuichi, Tadashi Mio, Keiichi Takigawa, Ilja Striz, Debra J. Romberger, Richard A. Robbins, John R. Spurzem, Peggy Heires, Stephen I. Rennard. Pulmonary and Critical Care Medicine Section, Department of Internal Medicine, University of Nebraska Medical Center APStracts 4:0145L, 1997.
• Pulmonary artery smooth muscle cell [ca2+]i and contraction: responses to diphenyleneiodonium and hypoxia. Zhang, F., R. C. Carson, H. Zhang, G. Gibson, and H. M. Thomas, Iii. Will Rogers Pulmonary Research Laboratory, Division of Pulmonary and Critical Care Medicine, and Dementia Research Service, Department of Neurology and Neurosciences; Cornell University Medical College & Burke Medical Research Institute, White Plains, NY 10605. APStracts 4:0146L, 1997.
• Alveolar epithelial cells in vitro produce gelatinases and tissue inhibitor of matrix metalloproteinase 2. D'ortho, Marie-Pia, Christine Clerici_, Pin Mei Yao, Christophe Delacourt, Christopheedelclaux, Marie-Laure Franco-Montoya, Alain Harf, and Chantalelafuma. Unit_ U296 de l'Institut National de la Sant_ et de la Recherche M_dicale and D_partement de Physiologie, Facult_ de M_decine, 94010 Cr_teil, France., _ Laboratoire de Physiologie, UFR de Sant_, Universit_ Paris XIII, 93000 Bobigny, France. APStracts 4:0147L, 1997.
• Genetic modeling of susceptibility to nitrogen dioxide-induced lung injury in mice. Holroyd, Kenneth J., Scott M. Eleff, Liu-Yi Zhang, George J. Jakab, and Steven R. Kleeberger. Departments of Environmental Health Sciences and Anesthesiology and Critical Care Medicine, The Johns Hopkins Medical Institutions, Baltimore, Maryland 21205 APStracts 4:0148L, 1997.
• Pulmonary dysfunction in neonatal sp-b deficient mice. Tokieda, Keisuke, Jeffrey A. Whitsett, Jean C. Clark, Timothy E. Weaver, Kazushige Ikeda, Keith B. McConnell, Alan H. Jobe[alpha], Machiko Ikegami[alpha], Harriet S. Iwamoto. Divisions of Neonatology and Pulmonary Biology, Childrens Hospital Medical Center, Cincinnati, Ohio 45229-3039; [alpha]Harbor-UCLA Medical Center, Department of Pediatrics, Torrance, CA 90509 APStracts 4:0149L, 1997.
• Gm-csf expression enhances lung growth and causes alveolar type ii epithelial cell hyperplasia in transgenic mice.. Reed, Jacquelyn A. Huffman, Ward R. Rice, Zsuzsanna K. Zsengell_r, Susan E. Wert, Glenn Dranoff, Jeffrey A. Whitsett. Division of Pulmonary Biology, Children's Hospital Medical Center, Cincinnati, Ohio 45229-3039, Dana Farber Cancer Institute, Harvard Medical School, Boston, Massachusetts 02115 APStracts 4:0150L, 1997.
• The nature of leukocyte shape changes in the pulmonary capillaries. Redenbach, Darlene M., Dean English, and James C. Hogg. University of British Columbia Pulmonary Research Laboratory, St. Paulaes Hospital, Vancouver, B.C. APStracts 4:0151L, 1997.
• Surfactant metabolic consequences of overexpression of gm-csf in the epithelium of gm-csf deficient mice. Ikegami, Machiko, Alan H. Jobe, Jacquelyn A. Huffman Reed, Jeffrey A. Whitsett. Department of Pediatrics, UCLA School of Medicine, Harbor-UCLA Medical Center, Torrance, CA 90502, Division of Pulmonary Biology, Children's Hospital Medical Center, Cincinnati, OH 45229 APStracts 4:0152L, 1997.
• Cyclic amp and purinergic2y-receptors up-regulate and enhance inducible nitric oxide synthase mrna and protein in vivo. Greenberg, Stan S., Xinfang Zhao, Ji-Fang Wang, Li Hua, and Jie Ouyang. Departments of Medicine and Physiology, The Alcohol Research Center, Louisiana State Univ. Medical Center, New Orleans, LA, 70112 APStracts 4:0153L, 1997.
• Macrophages primed by overnight culture demonstrate a marked stimulation of surfactant protein-a degradation. Bates, Sandra R., Jin Xu, Chandra Dodia, and Aron B. Fisher. The Institute for Environmental Medicine, University of Pennsylvania, School of Medicine, Philadelphia, PA 19104-6068 APStracts 4:0154L, 1997.
• Exosurf enhances adenovirus-mediated gene transfer to alveolar type ii cells. Manuel, S. Machelle, Yi Guo, and Sadis Matalon. Departments of Anesthesiology1, Physiology, and Biophysics, and Pediatrics, University of Alabama at Birmingham, Birmingham, AL 35233-6810 APStracts 4:0155L, 1997.
• Hyperoxia inhibits fetal rat lung fibroblast proliferation and expression of procollagens. Hussain, Naveed, Fengying Wu, Constance Christian, and Mitchell J. Kresch. From the Department of Pediatrics, Division of Neonatology, the University of Connecticut School of Medicine Farmington, Connecticut, U.S.A. 06030-2203 APStracts 4:0156L, 1997.
• Heterogeneity of the composition and thickness of tracheal mucus in rats. Sims, David E., and Margaret M. Horne. Department of Anatomy & Physiology, Atlantic Veterinary College, University of Prince, Edward Island, Charlottetown, PEI Canada C1A 4P3, SIMS@UPEI.CA APStracts 4:0157L, 1997.
• Ascorbate deficiency and oxidative stress in the alveolar type ii cell. Brown, Lou Ann S., Frank L. Harris, and Dean P. Jones. Departments of Pediatrics and Biochemistry, Emory University School of Medicine APStracts 4:0158L, 1997.
• Role of protein kinase c in calcium sensitization during muscarinic stimulation in airway smooth muscle. Bremerich, Dorothee H., David O. Warner, Robert R. Lorenz, Robin Shumway, Keith A. Jones. Departments of Anesthesiology, and Physiology and Biophysics, Mayo Clinic and Mayo Foundation, Rochester, MN, 55905 APStracts 4:0159L, 1997.
• Impairment of cation transport in a549 cells and rat alveolar epithelial cells by hypoxia. Mairb[umlaut]aurl, Heimo, Ralf Wodopia, Sigrid Eckes, Susanne Schulz, and Peter B[umlaut]artsch,. Department of Sports Medicine, University of Heidelberg, Heidelberg, Germany APStracts 4:0160L, 1997.
• Involvement of the ice family of proteases in silica-induced apoptosis in human alveolar macrophages. Iyer, Rashi, and Andrij Holian. Division of Pulmonary and Critical Care Medicine, Department of Internal Medicine, Toxicology Program, University of Texas Medical School, Houston, Texas 77030 APStracts 4:0161L, 1997.
• Rhinovirus stimulation of interleukin-8 in vivo and in vitro: role of nf-kb. Zhu, Zhou, Weiliang Tang, Jack M. Gwaltney, Jr., Yang Wu, and Jack A. Elias. Yale University School of Medicine, Section of Pulmonary and Critical Care Medicine, Department of Internal Medicine, 333 Cedar Street, LCI 105, New Haven, CT 06520-8057, Phone (203) 785-4163 / Fax (203) 785-3826, Division of Epidemiology and Virology, Department of Internal Medicine, University of Virginia Health Sciences Center, Box 473, Charlottesville, VA 22908, Phone (804) 924-2093 / Fax (804) 924 -0491, Division of Epidemiology and Virology, Department of Internal Medicine, University of Virginia Health Sciences Center, Box 473, Charlottesville, VA 22908, Phone (804) 924-2093 / Fax (804) 924 -0491 APStracts 4:0162L, 1997.
• Oxidant stress regulates basal endothelin-1 production by cultured rat pulmonary endothelial cells. Michael, John R., Boaz A. Markewitz, and Donald E. Kohan. Divisions of Respiratory, Critical Care and Occupational Pulmonary Medicine and Nephrology and Hypertension [tilde]n, Department of Medicine, Veterans Affairs Medical Center and University of Utah School of Medicine, Salt Lake City, Utah 84132 and Section of Pulmonary & Critical Care Medicine , Department of Medicine, Overton Brooks Veterans Affairs Medical Center, Louisiana State University School of Medicine, Shreveport, Louisiana. APStracts 4:0163L, 1997.
• Differential induction of c-fos, c-jun, and apoptosis in lung epithelial cells exposed to reactive oxygen and nitrogen species. Janssen, Yvonne M. W., Sadis Matalon, and Brooke T. Mossman. Department of Pathology, University of Vermont, Medical Alumni Building, Burlington, VT 05405, and Department of Anesthesiology, University of Alabama, Birmingham, AL APStracts 4:0164L, 1997.
• Regulation of cyclic guanosine monophosphate by soluble and particulate guanylyl cyclases in cultured human airway smooth muscle.. Hamad, Ahmed M., Simon Range, Elaine Holland, and Alan J. Knox. Respiratory Medicine Unit, City Hospital, Hucknall Road, Nottingham NG5 1PB, England, U.K. APStracts 4:0165L, 1997.
• Dexamethasone upregulates the na,k-atpase in rat alveolar epithelial cells. Barquin, Nora, David E. Ciccolella, Karen M. Ridge, and J. Iasha Sznajder (with The Assistance Of Malena Passos). Pulmonary and Critical Care Medicine, Michael Reese Hospital and Medical Center, University of Illinois at Chicago, and Instituto Nacional de Enfermedades Respiratorias˙2E APStracts 4:0166L, 1997.
• Hypoxia stimulates human preproendothelin-1 (ppet-1) promoter activity in transgenic mice. Aversa, Catherine R., Suzanne Oparil, Jaime Caro, Huaibin Li, Shuang -Dan Sun, Yiu-Fai Chen, Mavis R. Swerdel, Thomas M. Monticello, Stephen K. Durham, Alexander Minchenko_, Sergio A. Lira, and Maria L. Webb. Departments of Cardiovascular Biochemistry, Experimental Pathology, and Oncology, Bristol-Myers Squibb Pharmaceutical Research Institute, Princeton, NJ 08543, Vascular Biology and Hypertension Program, University of Alabama at Birmingham, Birmingham, Alabama 35294, and Department of Medicine, Thomas Jefferson University, Philadelphia, PA 19107 APStracts 4:0167L, 1997.
• Biosynthesis of sulfated extracellular matrices by alveolar type ii cells increases with time in culture. Sannes, Philip L., Jody Khosla, and Barry P. Peters. Department of Anatomy, Physiological Sciences, and Radiology, College of Veterinary Medicine, North Carolina State University, Raleigh, NC APStracts 4:0168L, 1997.
• Recombinant thrombomodulin prevents the endotoxin-induced increase in pulmonary vascular permeability through protein c activation. Uchiba, Mitsuhiro, Kenji Okajima, Kazunori Murakami, Masayoshi Johno, Mitsunobu Mohri, Hiroaki Okabe, and Kiyoshi Takatsuki. Departments of Medicine, Laboratory Medicine, and Dermatology, Kumamoto University School of Medicine, Kumamoto and 4Asahi Chemical Industry Co,. Ltd., Institute for Life Science Research Laboratory, Shizuoka, Japan. APStracts 4:0169L, 1997.
• Divergent regulation of 92 kda gelatinase and timp-1 by human bronchial epithelial cells in response to il-1[beta] and tnf.. Yao, P. M., B. Maitre, C. Delacourt, J. M. Buhler, A. Harf, and C. Lafuma. INSERM Unit[acute]e U296 and D[acute]epartement de Physiologie, Facult[acute]e de M[acute]edecine, 94010 Cr[acute]eteil, France, D[acute]epartement de Biologie Cellulaire et Mol[acute]eculaire, Commissariat [grave]a l'Energie Atomique, 91191 Gif-sur Yvette, France APStracts 4:0170L, 1997.
• Overexpression of metallothionein decreases the sensitivity of pulmonary endothelial cells to oxidant injury. Pitt, Bruce R., Margaret Schwarz, Elizabeth S. Woo, Emily Yee, Karla Wasserloos, Sothi Tran, Weili Weng, Robert J. Mannix, Simon A. Watkins, Yulia Y. Tyurina, Vladimir A. Tyurin, Valerian E. Kagan, and John S. Lazo. Departments of Pharmacology, Cell Biology and Physiology and Environmental Health and Occupational Medicine, University of Pittsburgh School of Medicine, Pittsburgh, PA 15261 APStracts 4:0171L, 1997.
• Contribution of type i (nnos) to expired gas no and bronchial responsiveness in mice.. Sanctis, George T. De, Sanjay Mehta, Lester Kobzik, Chandri Yandava, Aiping Jiao, Paul L. Huang, and Jeffrey M. Drazen. Pulmonary and Critical Care Division, Department of Medicine, Department of Pathology, Brigham and Womens Hospital, Cardiac Unit and Cardiovascular Research Center, Massachusetts General Hospital, and Harvard Medical School, Boston, MA. Respiratory Division, Department of Medicine, London Health Sciences Centre - Victoria Campus, University of Western Ontario, London, Ontario, Canada. APStracts 4:0172L, 1997.
• Surfactant convertase action is not essential for surfactant film formation. Gross, N. J., R. Veldhuizen, F. Possmayer, R. Dhand. Medical Service, Hines Veterans Affairs Hospital, Hines IL, 60141, USA, Department of Medicine, Stritch School of Medicine, Loyola University of Chicago, Stritch School of Medicine, Loyola University of Chicago, Maywood IL, USA, Department of Molecular and Cellular Biochemistry, Stritch School of Medicine, Loyola University of Chicago, Maywood IL, USA, Departments of Medicine and Physiology, Lawson Research Institute, University of Western Ontario, London, Canada, Departments of Obstetrics & Gynaecology, and Biochemistry, Medical Research Council Group in Fetal and Neonatal Health and Development, University of Western Ontario, London, Canada APStracts 4:0173L, 1997.
• Role of extracellular signal-regulated protein kinases in apoptosis by asbestos and h2o2. Jim[acute]enez, Luis Albert, Christine Zanella, Hua Fung, Yvonne M. W. Janssen, Pam Vacek, Colette Charland, Jonathan Goldberg, and Brooke T. Mossman. Departments of Pathology, Biostatistics, and Medicine, University of Vermont, College of Medicine, Burlington, VT 05405 APStracts 4:0174L, 1997.
• Glucocorticoid regulation of surfactant components in immature lambs. Ballard, Philip L., Yue Ning, Daniel Polk, Machiko Ikegami, Alan H. Jobe. Department of Pediatrics, University of Pennsylvania School of Medicine, Children's Hospital of Philadelphia, Philadelphia, PA, Department of Pediatrics, Harbor UCLA Medical Center, Torrance, CA APStracts 4:0175L, 1997.