Renal potassium transport: mechanisms and regulation.
Giebisch, Gerhard.
Department of Cellular and Molecular Physiology, Yale University
School of Medicine, 333 Cedar Street, New Haven, Conn.
APStracts 5:0010F, 1998.
The regulation of potassium metabolism involves mechanisms for the
appropriate distribution between the intra- and extracellular fluid
compartments and for the excretion by the kidney. Clearance and
single nephron studies show that renal excretion is determined by
regulated potassium secretion and potassium reabsorption respectively
in principal and intercalated cells of the distal nephron.
Measurement of the electrochemical driving forces acting on potassium
transport across individual cell membranes and characterization of
several ATPases and potassium channels provide insights into the
transport and regulation of renal potassium excretion.
Received 8 January 1998; accepted in final form 8 January 1998.
APS Manuscript Number F06-8.
Article publication pending Am. J. Physiol. (Renal Physiology).
ISSN 1080-4757 Copyright 1998 The American Physiological Society.
Published in APStracts on 28 January 1998