Differential regulation of romk expression in kidney cortex and
medulla by aldosterone and potassium.
Wald, H., H. Garty, L. G. Palmer and M. M. Popovtzer.
Nephrology and Hypertension Services, Hadassah University Hospital,
Jerusalem, and 2Department of Biological Chemistry, The Weizman
Institute of Science, Rehovot, Israel, and 3Department of Physiology
and Biophysics, Cornell University Medical College, New York, NY,
USA
APStracts 5:0089F, 1998.
This study explores the role of K+ and aldosterone in the regulation
of ROMK mRNA in the rat kidney. K+ deficiency downregulated ROMK mRNA
in cortex to 47.1 + 5.1% of control p<0.001, and in medulla to
56.1+ 3.4 p<0.001. High K diet slightly increased ROMK mRNA in
medulla to 122 + 9% p<0.05 vs. control. Adrenalectomy downregulated
cortical ROMK mRNA to 30.7 + 6.8 p<0.001 vs. control, and increased
it in medulla to 138 + 12.9 p<0.02 vs. control.
Received 11 December 1997; accepted in final form 30 April 1998.
APS Manuscript Number F392-7.
Article publication pending Am. J. Physiol. (Renal Physiology).
ISSN 1080-4757 Copyright 1998 The American Physiological Society.
Published in APStracts on 8 May 1998