APStracts 5:0125F, 1998.

Role of nitric oxide in the control of renin secretion. Kurtz, Armin, and Charlotte Wagner. Institut f[umlaut]ur Physiologie der Universit[umlaut]at Regensburg, Germany

APStracts 5:0125F, 1998.

During the last decade a number of in vivo and in vitro studies have been performed to characterize the physiological role of nitric oxide (NO) in the control of renal renin synthesis and secretion. These studies, conducted under a variety of different experimental conditions, have, however, produced conflicting results and have led to controversy about the role of NO in control of renin secretion (cf. 113; 118). Therefore, there is currently no clear concept about the physiological impact of NO in the regulation of renin secretion and synthesis nor in its mode of action in renal juxtaglomerular granular (JGG) cells (113). This contribution therefore aims to bring some order in the puzzling situation by sorting the findings with respect to comparable experimental conditions. Furthermore, we will attempt to develop a consensus about the possible action of NO in renal juxtaglomerular granular (JGG) cells.

Received 14 July 1998; accepted in final form 14 July 1998.
APS Manuscript Number F173-8.
Article publication pending Am. J. Physiol. (Renal Physiology).
ISSN 1080-4757 Copyright 1998 The American Physiological Society.
Published in APStracts on 21 September 1998