Gene transfer in the kidney.
Kelley, Vicki Rubin, and Vikas P. Sukhatme.
1Renal Division, Molecular Autoimmunity, Brigham and Women_s
Hospital, Harvard Medical School, Boston MA 02115; and 2Renal
Division, Beth Israel Deaconess Medical Center, Harvard Medical
School, Boston MA 02215
APStracts 5:0143F, 1998.
Human gene transfer, once considered a fantasy, is a clinical reality.
Gene transfer approaches offer the promise of revolutionizing
medicine. In this review we focus on the current and future prospects
for gene transfer into the kidney. We will discuss the concepts of
somatic gene transfer, the general considerations of gene transfer,
and review the pros and cons of current vectors systems. We will then
address the unique features of the kidney which dictate the selection
of a gene transfer strategy and review ex vivo and in vivo gene
delivery approaches tailored for the kidney. Finally, we will
speculate on the future directions and application of gene transfer
systems to combat kidney transplant rejection, autoimmune,
polycystic, malignant, and other acute glomerular and chronic
interstitial kidney diseases.
Received 17 Augsut 1998; accepted in final form 17 August 1998.
APS Manuscript Number F213-8.
Article publication pending Am. J. Physiol. (Renal Physiology).
ISSN 1080-4757 Copyright 1998 The American Physiological Society.
Published in APStracts on 21 September 1998