Endurance exercise causes interaction among stress hormones,
cytokines, neutrophil dynamics, and muscle damage.
Suzuki, Katsuhiko, Manabu Totsuka, Shigeyuki Nakaji, Mutsuo Yamada,
Satoru Kudoh, Qiang Liu, Kazuo Sugawara, Kanemitsu Yamaya, and Koki
Sato.
1 Department of Hygiene, Hirosaki University School of Medicine, 5
Zaifu-cho, Hirosaki, Aomori 036-8562, Japan; 2 Department of Health
and Physical Education, Faculty of Education, Hirosaki University, 1
Bunkyo-cho, Hirosaki, Aomori 036-8560, Japan; and 3 Oyokyo Kidney
Research Institute, 90 Yamazaki, Kozawa, Hirosaki, Aomori 036-8243,
Japan.
APStracts 6:0279A, 1999.
We analyzed adaptation mechanisms regulating systemic inflammatory
response of the stressed body using an experimental challenge of
repeated exercise bouts and accompanying muscle inflammation. Eight
untrained men bicycled at 90 watts for 90 min 3 days in a row.
Exercise induced peripheral neutrophilia with a left shift of
neutrophil nucleus and neutrophil priming for oxidative activity
determined by luminol-dependent chemiluminescence. Plasma growth
hormone and interleukin 6 rose significantly following exercise, and
were closely correlated with the neutrophil responses. Serum creatine
kinase and myoglobin levels as muscle damage markers rose after
exercise in delayed onset and were closely correlated with the
preceding neutrophil responses. These exercise-induced responses were
strongest on Day 1, but magnitude gradually decreased with
progressive daily exercise. In contrast, the magnitude of
catecholamine responses to exercise sessions gradually rose, possibly
suppressing neutrophil oxidative responses. These results indicate
that stress-induced systemic release of bioactive substances may
determine neutrophil mobilization and functional status, which then
may affect local tissue damage of susceptible organs.
Received 30 November 1998; accepted in final form 1 June 1999.
APS Manuscript Number A1085-8.
Article publication pending Journal of Applied Physiology.
ISSN 1080-4757 Copyright 1999 The American Physiological Society.
Published in APStracts on 25 June 1999