Endurance training and GH administration in elderly women: effects on abdominal adipose tissue lipolysis. Lange, Kai Henrik Wiborg, Jeanne Lorentsen, Fredrik Isaksson, Anders Juul, Michael Højby Rasmussen, Niels Juel Christensen, Jens Bülow, and Michael Kjær. 1Sports Medicine Research Unit, Bispebjerg Hospital, DK-2400; 2Department of Clinical Physiology, Bispebjerg Hospital, DK-2400 Copenhagen NV; 3Copenhagen Muscle Research Center, Rigshospitalet, DK-2100; 4Department of Growth and Reproduction, Rigshospitalet, DK-2100 Copenhagen; 5Clinical Drug Development, Novo Nordisk A/S, DK-2880 Bagsvaerd; and 6Department of Endocrinology, Herlev Hospital, DK-2730 Herlev, Denmark
APStracts 8:0030E, 2001.
In the present study, the effect of endurance training alone and endurance training combined with recombinant human growth hormone (rhGH) administration on subcutaneous abdominal adipose tissue lipolysis was investigated. Sixteen healthy women [age, 75 ± 2 yr (mean ± SE)] underwent a 12-wk endurance training program on a cycle ergometer. rhGH was administered in a randomized, double-blinded, placebo- controlled design in addition to the training program. Subcutaneous abdominal adipose tissue lipolysis was estimated by means of microdialysis combined with measurements of subcutaneous abdominal adipose tissue blood flow (ATBF; 133Xe washout). Whole body fat oxidation was estimated simultaneously by indirect calorimetry. Before and after completion of the training program, measurements were performed both at rest and during 60 min of continuous cycling at a workload corresponding to 60% of pretraining peak oxygen uptake «vo2peak». Endurance training alone did not effect subcutaneous abdominal adipose tissue lipolysis either at rest or during exercise as reflected by identical levels of interstitial adipose tissue glycerol, subcutaneous abdominal ATBF, and plasma nonesterified fatty acids (NEFA) before and after completion of the training program. Similarly, no effect on subcutaneous abdominal adipose tissue lipolysis was observed when combining endurance training with rhGH administration. However, in both the placebo and the GH groups, fat oxidation was significantly increased during exercise performed at the same absolute workload after completion of the training program. We conclude that the changed lipid metabolism during exercise observed after endurance training alone or after endurance training combined with rhGH administration is not due to alterations in subcutaneous abdominal adipose tissue metabolism in elderly women. 

Received 5 June 2000; accepted in final form 5 February 2001
APS Manuscript Number E249-0.
Article publication pending Am J Physiol Endocrinol Metab
ISSN 1080-4757 Copyright 2001 The American Physiological Society.
Published in APStracts on 27 February 2001