Invited Review: Plasticity and energetic demands of contraction in skeletal and
cardiac muscle.
Sieck, Gary C., and Michael Regnier.
Departments of Anesthesiology and Physiology, Mayo Medical School and
Foundation, Rochester, Minnesota 55905; and Department of Bioengineering, University
of Washington School of Medicine, Seattle, Washington 98195
APStracts 7:0048A, 2000.
Numerous studies have explored the energetic properties of skeletal and cardiac muscle
fibers. In this mini-review, we specifically explore the interactions between actin and
myosin during cross-bridge cycling and provide a conceptual framework for the
chemomechanical transduction that drives muscle fiber energetic demands. Because the
myosin heavy chain (MHC) is the site of ATP hydrolysis and actin binding, we focus on
the mechanical and energetic properties of different MHC isoforms. Based on the
conceptual framework that is provided, we discuss possible sites where muscle
remodeling may impact the energetic demands of contraction in skeletal and cardiac
muscle.
APS Manuscript Number A1226-0.
Article publication pending J Appl Physiol
ISSN 1080-4757 Copyright 2000 The American Physiological Society.
Published in APStracts on 29 January 2001