Role of ventilation strategy on perfluorochemical evaporation from the lungs.
Jeng, Mei-Jy, Daniele Trevisanuto, Carla M. Weis, William W. Fox, Aaron B. Cullen,
Marla R. Wolfson, and Thomas H. Shaffer.
1Institute of Clinical Medicine, National Yang-Ming University School of Medicine,
Taipei; 2Department of Pediatrics, Children's Medical Center, Veterans General
Hospital-Taipei, Taipei, Taiwan; 3Department of Pediatrics, Padua University, Padua,
Italy; 4Department of Neonatology, Children's Hospital of Philadelphia, University of
Pennsylvania School of Medicine; and 5Departments of Physiology and Pediatrics,
Temple University School of Medicine, Philadelphia, Pennsylvania 19140
APStracts 8:0005A, 2001.
To study the effect of ventilation strategy on perfluorochemical (PFC) elimination profile
(evaporative loss profile; EL), 6 ml/kg of perflubron were instilled into anesthetized
normal rabbits. The strategy was to maintain minute ventilation («ve», in ml/min) in three
groups «ve»L (208 ± 2), «ve»M (250 ± 9), and «ve»H (393 ± 1) over 4 h. In three other
groups, respiratory rate (RR, breaths/min) was controlled at 20, 30, or 50 with a constant
«ve» and adjusted tidal volume. PFC content in the expired gas was measured, and EL
was calculated. There was a significant «ve»- and time-dependent effect on EL. Initially,
percent PFC saturation and loss rate decreased in the «ve»H > «ve»M > «ve»L
groups, but by 3 h the lower percent PFC saturation resulted in a loss rate such that
«ve»H < «ve»M < «ve»L at 4 h. For the groups at constant «ve», there was a
significant time effect on EL but no RR effect. In conclusion, EL profile is dependent on
«ve» with little effect of the RR-tidal volume combination. Thus measurement of EL and
«ve» should be considered for the replacement dosing schemes during partial liquid
ventilation.
Received 19 September 2000; accepted in final form 26 October 2000
APS Manuscript Number A0799-0.
Article publication pending J Appl Physiol
ISSN 1080-4757 Copyright 2001 The American Physiological Society.
Published in APStracts on 29 January 2001