Relationship between renal sympathetic nerve activity and arterial pressure during
REM sleep in rats.
Miki, Kenju, Makiko Kato, and Suzuko Kajii.
Department of Environmental Health, Life Science, and Human Technology, Nara
Women's University, Kita-Uoya Nishimachi, Nara, 630«hyphen»8506, Japan
APStracts 9:0301R, 2002.
The relationship between renal sympathetic nerve activity (RSNA) and systemic arterial
pressure obtained during rapid eye movement (REM) sleep was compared with that
obtained in other sleep and awake states. Electrodes for the measurements of RSNA,
electrocardiogram, electromyogram, and electroencephalogram and a catheter for the
measurement of systemic arterial pressure were implanted under aseptic conditions at
least 5 days before the experiment. During the transition from non-REM (NREM) to
REM sleep, RSNA, and heart rate (HR) decreased immediately by 46 ± 2% (P < 0.05)
and 22 ± 3 beats/min (P < 0.05), respectively, over 3 s after the onset of REM sleep.
Meanwhile, systemic arterial pressure increased gradually after the onset of REM sleep,
which was apparently independent of the changes in RSNA. During REM sleep, the
relationships between RSNA/HR and systemic arterial pressure were dissociated
compared with that obtained during the other behavioral states. These data indicate that
the interdependency between systemic arterial pressure and RSNA during REM sleep is
likely to be modified compared with other behavioral states.
Received 23 January 2002; accepted in final form 4 October 2002
APS Manuscript Number R45-2.
Article publication pending Am J Physiol Regul Integr Comp Physiol
ISSN 1080-4757 Copyright 2002 The American Physiological Society.
Published in APStracts on 25 November 2002