Higher Cognitive Functions in Pediatric Patients with Brain Disease or Injury


Faraneh Vargha-Khadem, Ph.D.
Institute of Child Health, England

Course Prerequisites:  


  

Course Description:  

This course will cover the following topics:

Reading List

 

 

I           Speech and Language Outcome

 

Stroke and Cerebrovascular Disease

 

Vargha-Khadem F, Isaacs E, van der WS, Robb S, Wilson J. (1992).  Development of intelligence and memory in children with hemiplegic cerebral palsy. The deleterious consequences of early seizures. Brain, 115 Pt 1: 315-329.

Goodman R, Yude C. (1996).  IQ and its predictors in childhood hemiplegia. Dev Med.Child Neurol., 38: 881-890.

Isaacs E, Christie D, Vargha-Khadem F, Mishkin M. (1996).  Effects of hemispheric side of injury, age at injury, and presence of seizure disorder on functional ear and hand asymmetries in hemiplegic children. Neuropsychologia,  34: 127-137.   pdf

Nass-R. (1997). Language development in children with congenital strokes. Seminars in Pediatric Neurology, 4: 109-116.

Neville-HJ, Bavelier-D. (1998). Neural organisation and plasticity of language. Curr.Opin.Neurobiol., 8: 254-258.  pdf

Bates, Vicari-S, Trauner DA. (1999). Neural mediation of language development: Perspectives from lesion studies of infants and children. In: Tager-Flusberg-H, editor. Neurodevelopmental Disorders. Massachusetts: The MIT Press, 533-81.

Booth JR, Macwhinney B, Thulborn KR, Sacco K, Voyvodic J, Feldman HM.  (1999).  Functional organisation of activation patterns in children: Whole brain fMRI imaging during three different cognitive tasks. Progress in Neuro-Psychopharmacology, 23: 669-682.  pdf

Ganesan-V, Hogan AM, Shack-N, Isaacs EB, Kirkham FJ (2000). Outcome after ischaemic stroke in childhood. Develop.Med.Child Neurol. 42: 455-461.

Vargha-Khadem F., Isaacs E., Watkins K. and Mishkin M. (2000) Ontogenetic specialization of hemispheric function.  In Intractable Focal Epilepsy: Medical and Surgical Treatment, JM Oxbury, CE Polkey, and M Duchowney (eds.).   Harcourt Publishers, London, pp 405-418.



Hemispherectomy and Epilepsy

 

Vargha-Khadem, F. and Polkey, C. (1992) A review of cognitive outcome after hemidecortication in humans.  In Recovery From Brain Damage: Reflections and Directions, D. Rose and D. Johnson (eds.). Plenum Press, pp. 32-48.

 

Vargha-Khadem, F., Carr, L.J. , Isaacs, E., Brett, E., Adams, C., and Mishkin, M. (1997). Onset of speech after left hemispherectomy in a nine-year-old boy. Brain. 120, 159-182.  pdf

 

Vargha-Khadem, F. and Mishkin M. (1997) Speech and Language outcome after hemispherectomy in childhood.  In Paediatric Epilepsy Syndromes and Their Surgical Treatment, I. Tuxhorn, H. Holthausen and H.E. Boenigk (eds.). John Libbey & Company Ltd. Medical Books, pp. 774-784.

 

Holloway, V., Gadian, D.G., Vargha-Khadem, F., Porter, D.A., Boyd, S.G. and Connelly, A.  (2000).  The reorganisation of sensorimotor function in children after hemispherectomy: A functional MRI and somatosensory evoked potential study.  Brain, 123, 2432-2444.  pdf

 

Liegeois F., Connelly A., Salmond C., Gadian D.G., Vargha-Khadem F. and Baldeweg T. (2002). A direct test for lateralization of language activation using fMRI: comparison with invasive assessments in children with epilepsy.  Neuroimage. 17, 1861-1867.  pdf

 

Devlin, A.M., Cross, J.H., Harkness, W., Harding, B., Vargha-Khadem, F. and Neville, B. (2003). Clinical outcomes of hemispherectomy for epilepsy in childhood and adolescence. Brain. Vol. 126, No. 3, 556-566. pdf

 

Liegeois, F., Connelly, A., Cross, H., Gadian, D., Vargha-Khadem, F. and Baldeweg, T. (2004). Language reorganisation in children with early onset lesions of the left hemisphere: an fMRI study. Brain. Vol 127, Pt 6, 1229-1236.  pdf



Neurogenetic disorders

 

Bishop, DV, North, T, & Donlan C. (1995). Genetic basis of specific language impairment: evidence from a twin study. Dev.Med.Child Neurol. 37 (1):56-71.

 

Vargha-Khadem. F., Watkins, K., Alcock, K., Fletcher, P., and Passingham, R. (1995). Cognitive and praxic deficits in a large family with a genetically transmitted speech and language disorder.  Proceedings of the National Academy of Sciences, USA.  92, 930-933.  pdf

 

van der Lely, H. K. & Stollwerck, L. (1996). A grammatical specific language impairment in children: an autosomal dominant inheritance? Brain Lang, 52 (3):484-504. pdf

 

Tomblin, J. B. and Pandich, J. (1999).  Lessons from children with specific language impairment. Trends in Cognitive Sciences, 3 (8):283-285.  pdf

 

Bishop, D. V. (2000). How does the brain learn language? Insights from the study of children with and without language impairment. Dev.Med.Child Neurol. 42 (2):133-142. pdf

 

Alcock, K.J., Passingham, R.E., Watkins, K.E., Vargha-Khadem, F. (2000). Oral dyspraxia in inherited speech and language impairment and acquired dysphasia.  Brain and Language 75, 17-33.  pdf

 

Bishop, D. V. (2001) Genetic and environmental risks for specific language impairment in children. Philos.Trans.R.Soc.Lond B Biol.Sci. 356 1407:369-380.  pdf

 

Lai, C SL., Fisher, SE., Hurst, JA., Vargha-Khadem, F. & Monaco, A P. (2001). A novel forkhead-domain gene is mutated in a severe speech and language disorder.  Nature.  413, 519-523.   pdf

 

Meaburn, E, Dale, PS, Craig, WI & Plomin R. (2002). Language-impaired children: No sign of the FOXP2 mutation. NeuroReport, Vol 13, 8, pg. 1075-1077.  pdf

 

Newbury, DF, Bonora, E, Lamb, A, Fisher, S, Lai, CS, Baird, G, Jannoun, L, Slonims, V, Stoot, CM, Mericks, MJ, Bolton, PF & Bailey, AJ. (2002). FOXP2 Is Not a Major Susceptibility Gene for Autism or Specific Language Impairment. Am. J. Hum. Genet. 70:000-000.  pdf

 

Watkins, KE., Dronkers, N. and Vargha-Khadem, F. (2002). Behavioural analysis of an inherited speech and language disorder: Comparison with acquired aphasia.  Brain, 125, 452-464.  pdf

 

Watkins, KE., Vargha-Khadem, F., Ashburner, J., Passingham, RE., Connelly , A., Friston, KJ., Frackowiak, RSJ., Mishkin, M. &Gadian, DG. (2002). MRI analysis of an inherited speech and language disorder: structural brain abnormalities. Brain, 125, 465-478.  pdf

 

Belton, E., Salmond, C.H., Watkins, K.E., Vargha-Khadem, F. and Gadian, D.G. (2003). Bilateral brain abnormalities associated with dominantly inherited verbal and orofacial dyspraxia Human Brain Mapping.  Vol 18/3, 194-200. pdf

 

Liegeois, F., Baldeweg, T., Connelly, A., Gadian, D.G., Mishkin, M. and Vargha-Khadem, F. (2003).  Functional MRI abnormalities during covert speech associated with FOXP2 gene mutation. Nature Neuroscience.  Vol 6, No. 11, 1230-1237.  pdf

 

Vargha-Khadem, F., Gadian, D.G., Copp, A., and Mishkin, M.  (2005).  FOXP2 and the neuroanatomy of speech and language.  Nature Reviews Neuroscience.  Vol 6, 131-138.  pdf

 

Macdermot, K.D., Bonora, E., Sykes, N., Coupe, A.M., Lai, C.S., Vernes, S.C., Vargha-Khadem, F., McKenzie, F., Smith, R.L., Monaco, A.P. and Fisher, S.E. (2005).  Identification of FOXP2 Truncation as a Novel Cause of Developmental Speech and Language Deficits. Am. J. Hum. Genet. 76, 1074-1080.  pdf



Various

 

Alm, P.A. (2004). Stuttering and the basal ganglia circuits: A critical review of possible relations. J. Commun. Disord., 37, 325-369.  pdf

 

Bates, E., Reilly, J., Wulfeck, B., Dronkers, N., Opie, M., Fenson, J. et al (2001). Differential effects of unilateral lesions on language production in children and adults. Brain Lang, 79, 223-265.  pdf

 

Hillis, A.E., Work, M., Barker, P.B., Jacobs, M.A., Breese, E.L., & Maurer, K. (2004). Re-examining the brain regions crucial for orchestrating speech articulation. Brain, 127, 1479-1487. pdf

 

Kent, R.D. (2000). Research on speech motor control and its disorders: A review and prospective. J.Commun.Disord., 33, p 391-427.  pdf



II         Memory

 

Temporal Lobe Epilepsy and Lobectomy

 

Seidenberg, M, Hermann, B, Schoenfeld, J, Davies, K, Wyler, A, Dohan, F. (1997).  Reorganizaiton of verbal memory function in early onset left temporal lobe epilepsy. Brain and Cognition 35, 132-148.  pdf

 

Westerveld, M, Sass, K, Chelune, G, Hermann, B, Barr, W, Loring, D, Strauss, E, Trenerry, M, Perine, K, Spencer, D. (2000). Temporal lobectomy in children: Cognitive outcome. J Neurosurg. 92:24-30.

 

Hermann, B, Seidenberg, M, Bell, B, Rutecki, Sheth, R, Ruggles, K, Wendt, G, O'Leary, D & Magnotta, V. (2002). The neurodevelopmental impact of childhood-onset temporal lobe epilepsy on brain structure and function. Epilepsia, 43(9), 1062-1071.  pdf



Amnesia

 

Mishkin, M., Suzuki, W., Gadian, D. and Vargha-Khadem, F. (1997). Hierarchical Organization of Cognitive Memory.  In Philosophical Transactions: Biological Sciences. The Royal Society, 352, 1461-1467.  pdf

 

Vargha-Khadem, F., Gadian, D.C., Watkins, K.E., Connelly, A., Van Paesschen, W. and Mishkin, M., (1997). Differential effects of early hippocampal pathology on episodic and semantic memory.  Science 277, 376-380.  pdf

 

Aggleton, JP, Brown, MW. (1999). Episodic memory, amnesia and hippocampla-anterior thalamic axis.  Behavioural and Brain Sciences 22: 425-489.  pdf

 

Gadian, D.G., Aicardi, J., Watkins, K.E., Porter, D.A., Mishkin, M. and Vargha-Khadem, F. (2000). Developmental amnesia associated with early hypoxic-ischaemic injury.  Brain, 123, 499-507.  pdf

 

Gadian, D., Vargha-Khadem F. (2000). Magnetic resonance and memory function in children with focal brain damage.  Revue de Neuropsychologie, 10/3, p. 405-416. 

 

Baddeley, A., Vargha-Khadem, F. and Mishkin, M.  (2001).  Preserved recognition in a case of developmental amnesia: Implications for the acquisition of semantic memory? Journal of Cognitive Neuroscience, 13 (3) 357-369.   pdf

 

Düzel, E., Vargha-Khadem, F., Heinze, H.J., Mishkin, M. (2001).  Brain activity evidence for recognition without recollection after early hippocampal damage. Proceedings of the National Academy of Sciences, USA, 98 (14), 8101-8106.  pdf

 

Maguire, E., Mishkin, M., C., Vargha-Khadem, F. (2001). The effect of bilateral hippocampal damage on fMRI regional activations and interactions during memory retrieval.  Brain.  124, 1156-1170.  pdf

 

Vargha-Khadem, F., Gadian, D. and Mishkin, M. (2001)  Dissociations in cognitive memory: the syndrome of developmental amnesia.  Phil. Trans. R. Soc. Lond. B 356, 1435-1440.  pdf

 

Vargha-Khadem, F., Salmond, C. H., Watkins, K. E., Friston K. J., Gadian D. G. and Mishkin, M. (2003).  Developmental amnesia:  Effect of age at injury, PNAS – USA. Vol 100, No. 17, 10055-10060.  pdf


Isaacs, E.B., Vargha-Khadem, F., Watkins, K.E., Lucas, A., Mishkin, M. and Gadian, D.G. (2003).  The syndrome of developmental amnesia: relationship to degree of hippocampal atrophy, PNAS-USA. Vol. 100, No. 22, 13060-13063. pdf

King, J.A., Trinkler, I., Hartley, T., Vargha-Khadem, F. and Burgess, N. (2004). The hippocampal role in spatial memory and the familiarity-recollection distinction: A single case study.  Neuropsychology Vol 18, Issue 3, 405-417.  pdf

 

Adlam, A.R., Vargha-Khadem, F., Mishkin, M., and de Haan, M.  (2005).  Deferred imitation of action sequences in developmental amnesia.  Journal of Cognitive Neuroscience. Vol 17, 240-248.  pdf


Bachevalier, J. & Vargha-Khadem, F. (2005). The primate hippocampus: ontogeny, early insult and memory. Current. Opinion in. Neurobiology. 15, 168-174.  pdf



III        Neuroimaging

 

Ashburner, J. & Friston, K.J. (2000). Voxel-based morphometry – the methods. Neuroimage, 11, 805-821  pdf

 

Gadian, D.G., Isaacs, E.B., Cross, J.H., Connelly, A., Jackson, G.D., King, M.D. et al. (1996). Lateralization of brain function in childhood revealed by magnetic resonance spectroscopy. Neurology, 46, 974-977.