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Spina Bifida
Cortical Thickness:
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The objective of this project is to identify genetic, central nervous system, and environmental sources of variability that explain the variations in neurobehavioral outcomes associated with spina bifida meningomyelocele (SB), the most common severely disabling birth defect in North America.
Project 4 (Magnetic Source Imaging; Papanicolaou, PI) utilizes magnetic source imaging to evaluate the reorganization of motor, somatosensory, language, and cognitive skills in children with SB, representing one of the first functional neuroimaging studies of children with congenital brain injury.
This comprehensive program project will facilitate an integrated, multi-disciplinary understanding of SB and provides a model for other neurodevelopmental disorders with genetic heterogeneity, brain dysmorphologies, and variable neurobehavioral outcomes while utilizing magnetic source imaging (MSI) to evaluate the organization of brain functions in children with SB.
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Center for Clinical Neurosciences
Children's Learning Institute
University of Texas Houston Health Science Center
1333 Moursund Street Ste H114
Houston, Texas 77030
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