Center faculty members have well-established research programs
and are well funded for their research through both extramural
and intramural grants. The nine Principal Investigators form
a highly interactive group, and the Center is in the process of
being expanded with two new Assistant Professors with complementary
Investigators of the Center:
Spudich, Ph.D., Center Director
Structure and function of photoactive membrane receptors and
signal transduction triggered by light; rhodopsins and related
Macromolecular transport across procaryotic and eucaryotic membranes;
G protein mediated signal transduction; regulation of adenylyl
cyclase and production of cyclic AMP; regulators of G protein
signaling (RGS proteins); relaxin.
Structure, function and assembly of cell membranes; lipid-assisted
- Vasanthi Jayaraman, Ph.D.
Structure and function of ligand gated ion channels; spectroscopic investigations of membrane proteins.
- Renhao Li, Ph.D.
Structure/function and assembly of integrins; cell adhesion receptors; NMR
- John Putkey, Ph.D.
Structural and molecular biology of calcium-signaling mechanisms including cardiac muscle contraction, Ca2+ channels, and calmodulin and regulators of calmodulin signaling.
Henry Strobel, Ph.D.
Cytochrome P-450-dependent drug and carcinogen metabolism system;
neurobiology of drug action.
- Lei Zheng, Ph.D.
Structural biology of membrane proteins; ion transport and regulation; X-ray Crystallography.