Faculty
Research
The
Center faculty members have well-established research programs
and are well funded for their research through both extramural
and intramural grants. The nine Principal Investigators form
a highly interactive group, and the Center is in the process of
being expanded with two new Assistant Professors with complementary
research strength.
Principal
Investigators of the Center:
- John
Spudich, Ph.D., Center Director
Structure and function of photoactive membrane receptors and
signal transduction triggered by light; rhodopsins and related
heptahelical receptors.
- Peter
Christie, Ph.D.
Macromolecular transport across procaryotic and eucaryotic membranes;
bacterial pathogenicity.
- Carmen
Dessauer, Ph.D.
G protein mediated signal transduction; regulation of adenylyl
cyclase and production of cyclic AMP; regulators of G protein
signaling (RGS proteins); relaxin.
- William
Dowhan, Ph.D.
Structure, function and assembly of cell membranes; lipid-assisted
protein folding.
- Vasanthi Jayaraman, Ph.D.
Structure and function of ligand gated ion channels; spectroscopic investigations of membrane proteins.
- Renhao Li, Ph.D.
Structure/function and assembly of integrins; cell adhesion receptors; NMR
-
Ferid Murad, M.D., Ph.D., Nobel laureate
Nitric oxide and cyclic GMP; cell signaling; second messengers;
regulatory biology; molecular pharmacology.
- John Putkey, Ph.D.
Structural and molecular biology of calcium-signaling mechanisms including cardiac muscle contraction, Ca2+ channels, and calmodulin and regulators of calmodulin signaling.
- Kevin
Ridge, Ph.D.
Dynamic aspects of integral membrane protein structure; development
and application of high-throughput ligand screening approaches
for GPCR's.
-
Henry Strobel, Ph.D.
Cytochrome P-450-dependent drug and carcinogen metabolism system;
neurobiology of drug action.
- Lei Zheng, Ph.D.
Structural biology of membrane proteins; ion transport and regulation; X-ray Crystallography.
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