The University of Texas Health Science Center at Houston
Colorful photo of a DNA model
The Brown Foundation Institute of Molecular Medicine
for the Prevention of Human Diseases
 


David E. Volk, Ph.D.

Research Scientist
The Brown Foundation Institute of Molecular Medicine
Office 713.500.3195; Fax 713.500.0319
David.Volk@uth.tmc.edu

David Volk, Ph.D., joined the University of Texas Health Science Center Houston (UTHSC-H) in January 2009 as a Research Scientist following a 12 year career at the Sealy Center for Structural Biology & the Biochemistry and Molecular Biology Department of the University of Texas Medical Branch (UTMB) in Galveston, TX and a post-doctoral position at Duke University Medical Center. He has nearly 20 years experience using nuclear magnetic resonance spectroscopy to elucidate the structures of small organic chemicals, DNA strands and proteins. His research interests are generally related to human health and structural biology, and past work has included the study of cancer-causing DNA mutations, flavivrirus structures, immune regulation, DNA synthesis, quantum chemistry and Lewis acid-mediated stereochemistry.

Publications


(33)Structure of Yellow Fever Virus Envelope Protein Domain III.
D. E. Volk, F. J. May, S. H. Gandham, A. Anderson, J. von Lindern,
D. Beasley, A. D.T. Barrett and D. G. Gorenstein.
Virology394(1), 12-18, 2009.
(32)Investigation of Chemometric Instrumental Transfer Methods for High-Resolution NMR.
T. M. Alam, M. K. Alam, S. K. McIntyre, D. E. Volk, M. Neerathilingam & B. A. Luxon
Analytical Chemistry81(11), 4433-4443, 2009.
(31)NMR Assignments of the Sylvatic Dengue 1 Virus Envelope Protein Domain III.
D. E. Volk, K. M. Anderson, S. H. A. Gandham, F. J. May, L. Li, David W. C. Beasley, A. D. T. Barrett and D. G. Gorenstein
Biomol. NMR Assigments 2:155-157, 2008. PMC ID PMC2593834
(30) Base-pairing Properties of the Oxidized Cytosine Derivative, 5-Hydroxy Uracil.
V. Thiviyanathan, A. Somasunderam, D. E. Volk, T.K. Hazra, S. Mitra and D. G. Gorenstein
Biochem. Biophys. Res. Commun. 366:752-757, 2008.PubMed Central Version
(29) Ab initio base-pairing energies of an oxidized thymine product, 5-formyluracil,
with standard DNA bases at the BSSE-free DFT and MP2 theory levels.
D. E. Volk, V. Thiviyanathan, A. Somasunderam and D. G. Gorenstein,
Org. Biomol. Chem. 2007, 5(10), 1554-1558.
(28) NMR Assignments of the Yellow Fever Virus Envelope Protein Domain III
D. E. Volk, S. A. Gandham, F. J. May, A. Anderson, A. D. T. Barrett and D. G. Gorenstein.
Biomolecular NMR Assignments 2007, 1(1):49-50, 2007.
(27) Solution Structure of the Envelope Protein Domain III of Dengue-4 Virus
D. E. Volk, Y.-C. Lee, X. Li, V. Thiviyanathan, G. D. Gromowski, L. Li, A. Lamb, D. W. Beasley, A. D. T. Barrett and D. G. Gorenstein,
Virology 2007, 364(1), 147-154. (PMCID: PMC1950219)
(26) NMR Assignment of the Dengue 4 Virus Envelope Protein Domain III
D. E. Volk, Y.-C. Lee, X. Li, A. D. T. Barrett and D. G. Gorenstein,
Journal of Biomolecular NMR 2006, 36(suppl. 5):62.
(25) Ab Initio Base-pairing Energies of Uracil and 5-Hydroxy-Uracil with Standard DNA Bases at the BSSE-free DFT and MP2 Theory Levels
D. E. Volk, V. Thiviyanathan, A. Somasunderam and D. G. Gorenstein
Organic and Biomolecular Chemistry 2006, 4(9), 1741-1745.
(24) Structure of the Envelope Protein Domain III of Omsk Hemorrhagic Fever Virus.
D. E. Volk, L. Chavez, D. W. C. Beasley, A. D. T. Barrett, M. R. Holbrook and D. G. Gorenstein
Virology 2006, 351(1), 188-195.
(23) NMR structure of the viral peptide linked to the genome (VPg) of poliovirus.
C. Schein, N. Oezguen, D. E. Volk, R. Garimella, A. Paul and W. Braun
Peptides 2006, 27(7), 1676-1684. (PMCID: PMC ID PMC1629084)
(22) Novel, structure-based mechanism for uridylylation of the genome-linked peptide (VPg) of picornaviruses.
C. Schein, D. E. Volk, N. Oezguen, A. Paul and W. Braun
PROTEINS:Structure, Function, and Bioinformatics 2006, 63:719-726.
(21) Selection of Thioaptamers for Diagnostics and Therapeutics
X. Yang, H. Wang, D.W.C. Beasley, D. E. Volk, X. Zhao, B. A. Luxon,
L. O. Lomas, N. Herzog, J. F. Aronson, A.D.T. Barrett, J. F. Leary and D. G. Gorenstein
Annal. N. Y. Acad. Sci. 2006, 1082:116-119.
(20) 5-Hydroxy Uracil Can Form Stable Base Pairs With all Four Bases in a DNA Duplex.
V. Thiviyanathan, A. Somasunderam, D.E. Volk, and D.G. Gorenstein
Chemical Communications. 2005(3) 400-402.
(19) TATA-Box Binding Protein Induces Structure in the Recombinant Glucocorticoid Receptor AF1 Domain.
R. Kumar, D.E. Volk, J. Li, J.C. Lee, D.G. Gorenstein and E.B. Thompson
Proc. Nat. Acad. Sci. U.S.A. 2004, 101, 16425-16430. (PMCID: PMC534534)
(18) Solution structure and antibody binding studies of the envelope protein domain III from the New York strain of West Nile virus.
D.E. Volk, D. W. C. Beasley, D. A. Kallick, M.R. Holbrook, A.D.T. Barrett and D. G. Gorenstein
J. Biolog. Chem. 2004, 279,38755-38761.
(17) 1H, 13C, and 15N resonance assignments for domain III of the West Nile Virus envelope protein.
D.E. Volk, D. A. Kallick, M.R. Holbrook, D.W.C. Beasley, A.D.T. Barrett and D.G. Gorenstein
J. Biomol. NMR 2004, 29, 445-446.
(16) NMR Structure of the Apo-S100P protein.
Y.-C. Lee, D.E. Volk, V. Thiviyanathan, Q. Kleerekoper, A.X. Gribenko, S. Zhang D.G. Gorenstein, G. I. Makhatadze and B. A. Luxon.
J. Biomol. NMR 2004, 29, 399-402.
(15) Solution Structure of a Cis-Opened (10R)-N6- Deoxyadenosine Adduct of
(9S,10R)-9,10-Epoxy-7,8,9,10-tetrahydrobenzo[a]pyrene in a DNA Duplex
D.E. Volk, V. Thiviyanathan, J.S. Rice, B.A. Luxon, J.H. Shah, H. Yagi, J.M. Sayer, D.M. Jerina, and D.G. Gorenstein
Biochemistry 2003, 42, 1410-1420.
(14)
Initiation of Repair of A:G Mismatches is Modulated by Sequence Context
A.M. Sanchez, D.E. Volk, D.G. Gorenstein, and R.S. Lloyd
DNA Repair 2003, 2(8), 863-878.
(13) Solution Structure, Dynamics and Thermodynamics of the Native
State Ensemble of the Sem-5 C-terminal SH3 Domain
J.C. Ferreon, D.E. Volk, B.A. Luxon, D.G. Gorenstein and V.J. Hilser,
Biochemistry 2003, 42, 5582-5591.
(12) Solution structure and design of dithiophosphate backbone
aptamers targeting transcription factor NF-kappa B
D.E. Volk, X. Yang, S.M. Fennewald, D.J. King, S. Bassett,
S. Venkitachalam, N. Herzog, B.A. Luxon, and D.G. Gorenstein,
Bioorganic Chemistry 2002, 30, 396-419.
(11) An ab initio study of phosphorothioate and phosphorodithioate interactions with sodium cation.
D.E. Volk, T.D. Power, D.G. Gorenstein and B.A. Luxon,
Tetrahedron Letters 2002, 43, 4443-4447.
(10) Potential Double-Flipping Mechanism by E. coli MutY.
P.G. House, D.E. Volk, V. Thiviyanathan, R.C. Manual, B.A. Luxon, D.G. Gorenstein, and R.S. Lloyd,
Progress in Nucleic Acid Research and Molecular Biology, 2001, 68, 349-364.
(9) NMR Evidence for Syn-Anti Interconversion of a Trans Opened (10R)-dA Adduct of Benzo[a]pyrene (7S,8R)-Diol (9R,10S)-Epoxide in a DNA Duplex.
D.E. Volk, J.S. Rice, B.A. Luxon, H.J.C. Yeh, C. Liang, G. Xie, J.M. Sayer, D.M. Jerina, and D.G. Gorenstein,
Biochemistry 2000, 39, 14040-14053.
(8) Structural Similarities between MutT and the C-Terminal Domain of MutY.
D.E. Volk, P.G. House,V. Thiviyanathan, B.A. Luxon, S. Zhang, R.S. Lloyd and D.G. Gorenstein,
Biochemistry (Accelerated Publication) 2000, 39, 7331-7336.
(7) 1H, 13C, and 15N resonance assignments of the C-terminal domain of MutY: An Adenine glycosylase active on G:A mismatches.
D.E. Volk, V. Thiviyanathan, P.G. House, R.S. Lloyd and D.G. Gorenstein,
J. Biomol. NMR: 1999, 14, 385-386.
(6) SnCl4
S. Castellino and D.E. Volk,
"Encyclopedia of Reagents for Organic Synthesis".
Leo Paquette, Editor-in-Chief, Wiley: 1995.
(5) Allyltributylstannane
S. Castellino and D.E. Volk,
"Encyclopedia of Reagents for Organic Synthesis".
Leo Paquette, Editor-in-Chief, Wiley: 1995.
(4) Crotylstannane
S. Castellino and D.E. Volk,
"Encyclopedia of Reagents for Organic Synthesis".
Leo Paquette, Editor-in-Chief, Wiley: 1995.
(3) SnCl4/ZnCl2
S. Castellino and D.E. Volk,
"Encyclopedia of Reagents for Organic Synthesis".
Leo Paquette, Editor-in-Chief, Wiley: 1995.

(2) Chelation Controlled Reactions of Et2AlCl and Carbomethoxy Substituted Dioxolanes.
S. Castellino and D.E. Volk,
Tetrahedron Letters: 1993, 34, 967.
(1) Substituent Effects on the Gas Phase Acidity of Silane.
M.S. Gordon, D.E. Volk, and D.R. Gano,
J. Am. Chem. Soc.: 1989, 111, 9273.

 

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This site was created and last updated November 19, 2009 by David E. Volk Copyrigtht 2002-Present