Bingliang Fang, Ph.D. 1989, Hamburg University, Germany The University of Texas M. D. Anderson Cancer Center Department of Thoracic and Cardiovascular Surgery Contact Information

Research Interests:

• Tumor specific transgene expression
• Apoptotic genes
• Cancer gene therapy

The research in my laboratory is focused on an in vivo gene delivery for cancer therapy. Current study includes mechanisms of Bax and TRAIL mediated apoptotic pathways, use of proapoptotic and/or immune regulatory genes for treatment of cancers and targeted cancer gene therapy. We have recently developed vectors that can effectively express proapoptic genes in vitro and in vivo, and a technology that can target transgene expression to tumor cells. Our goals are developing technology for cancer treatments that are based on novel mechanisms of action, broadly applicable, and yet minimally toxic.

Depending on the student's interests, tutorial in my laboratory would provide experience in basic molecular biology, viral and nonviral vector construction, in vitro and in vivo tumor models and gene delivery technology.

Publications

Program Affiliation:

Program in Virology and Gene Therapy