Osama Mawlawi, Ph.D.

1999, Columbia University

UT M. D. Anderson Cancer Center
Imaging Physics

Research Interests: Positron Emission Tomography; kinetic modeling, image acquisition, reconstruction, and quantification; statistical parametric mapping

The research in my laboratory is directed at functional imaging using Positron Emission Tomography (PET). A strong interest lies in the factors affecting absolute quantification of PET images such as partial volume, scatter, and patient motion artifacts. Ongoing research is looking at novel techniques of image acquisition, correction and formation. Other interests lie in modeling the distribution of novel radiotracers to image specific biochemical processes such as metabolism, blood flow, receptor binding and expression.

A tutorial in my lab would provide the student with an in-depth experience of functional imaging using PET. Moreover, the student will get hands-on experience with image acquisition, reconstruction, and analysis software tools.

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Martinez D, Mawlawi O, Hwang DR, Kent J, Simpson N, Hasimoto T, Parsey RV, Slifstein M, Huang Y, Van Heertum R, Abi-Dargham A, Caltabiano S, Malizia A, Cowley H, Mann JJ, Laruelle M (2000) Positron Emission Tomography study of pindolol occupancy of 5-HT1A receptors in humans: preliminary analyses. Nucl Med Biol 27:523-527.

Parsey RV, Slifstein M, Hwang DR, Abi-Dargham A, Simpson N, Mawlawi O, Guo N, Van Heertum R, Mann JJ, Laruelle M (2000) Validation and reproducibility of measurement of 5- HT1A receptors parameters with [carbonyl-11C]Way-100635 in humans: comparison of artrial and reference tissue input functions. J Cereb Blood Flow Metab 20(7):1111-1133.

Martinez D, Hwang DR, Mawlawi O, Kent J, Simpson N, Hasimoto T, Parsey RV, Slifstein M, Huang Y, Van Heertum R, Abi-Dargham A, Caltabiano S, Malizia A, Cowley H, Mann JJ, Laruelle M (2001) Differential occupancy of somatodendritic and postsynaptic 5HT1A receptors by pindolol: A dose-occupancy study with [11C]WAY 100635 and Positron Emission Tomography in humans. Neuropsychopharmacology 24(3):209-229.

Program Affiliations:
Program in Medical Physics