Tinsu Pan, Ph.D.

1991, The University of Michigan

UT M. D. Anderson Cancer Center
Imaging Physics

Research Interests: (1) Image guided radiation therapy with PET/CT, 4D-CT, 4D-Cone Beam CT and 4D PET and (2) Cardiac PET/CT imaging.

My research is in imaging the anatomy with cardiac and/or respiratory motion such as the lung and hepatic tumors as well as the coronary arteries. The applications include image guided radiation therapy, PET perfusion, CT perfusion, and cardiac CT. We are using state-of-the-art PET/CT, CT and cone beam CT devices to bring new imaging acquisition and processing techniques to the clinic.

A student will learn the state-of-the-art research and equipments, and will gain knowledge of image guided radiation therapy, perfusion CT and cardiac PET/CT imaging.
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Nehmeh S.A., Erdi Y.E., Kalaigian, H., Kolbert K.S., Pan T., Yeung H., Squire O., Sinha A., Larson S.M., and Humm J.L. Correction for oral contrast artifacts in the CT attenuation corrected PET images of the Discovery LS PET/CT, J. Nuc. Med. 44(12): 1940-1944, 2003.

Pan T., Lee T.Y., Rietzel E. and Chen G.T.Y. 4D-CT imaging of a volume influenced by respiratory motion on multi-slice CT, Med. Phys. 31(2): 333-340, 2004.

Nehmeh S.A., Erdi Y.E., Pan T., York E., Mageras G.S., Rosenzweig K.E., Schoder H., Mostafavi H., Squire O., Pevsner A., Larson S.M., and Humm J.L. Quantitation of respiratory motion during 4D-PET/CT acquisition, Med. Phys. 31(6):1333-1338, 2004.

Erdi Y.E., Nehmeh S.A., Pan T., Pevsner A., Rosenzweig K.E., Mageras G.S., York E., Schoder H., Hsiao W., Squire O.D., Vernon P., Ashman J.B., Mostafavi H., Larson S.M., and Humm J.L. The CT motion quantitation of lung lesions and its impact on PET-measured SUVs, J. Nuc. Med. 45(8):1287-1292, 2004.

Nehmeh S.A., Erdi Y.E., Pan T., Pevsner A., Rosenzweig K.E., York E., Mageras G.S., Schoder H., Vernon P., Squire O., Mostafavi H., Larson S.M., and Humm J.L. Four-dimensional (4D) PET/CT imaging of the thorax, Med. Phys. 31(12):3179-3186, 2004.

Pan T. Comparison of helical and cine acquisitions for 4D-CT imaging with multi-slice CT, Med. Phys. 32(2):627-634, 2005.

Rietzel E., Pan T., and Chen G.T.Y. Four-dimensional computed tomography: imaging formation and clinical protocol, Med. Phys. 32(4):874-889, 2005.

Pan T., Mawlawi O., Nehmeh S.A., Erdi Y.E., Luo D., Liu H.H., Castillo R., Mohan R, Liao Z. and Macapinlac H.A. Attenuation correction of PET images with respiratory-averaged CT images on PET/CT, J. Nuc. Med. 46:1481-1487, 2005.

Mawlawi O., Erasmus J.J., Munden R.F., Pan T., Knight A.E., Macapinlac H.A., Podoloff D.A., and Chasen M. Quantifying the effect of intravenous contrast media on integrated PET/CT imaging clinical Evaluation. AJR 186:308-319, 2006.

Guerrero T., Sanders K., Castillo E., Zhang Y., Bidaut L, Pan T., and Komaki R. Dynamic ventilation imaging from four-dimensional computed tomography. Phys. Med. Biol. 51:777-791, 2006.

Mawlawi O., Erasmus J.J., Pan T., Cody D., Campbell R., Lonn A., Kohlmyer S., Macapinlac H.A., and Podoloff D.A. Truncation artifact in PET/CT imaging: impact on measurements of activity concentration and assessment of a correction algorithm. AJR 186:1458-1467, 2006.

Mawlawi O., Pan T., and Macapinlac H.A. PET/CT imaging techniques, considerations, and artifacts. J. Thoracic Imaging, 21(2):99-110, 2006.

Truong M.T., Pan T., and Erasmus J.J. Pitfalls in integrated CT-PET of the thorax: implications in oncologic imaging. J. Thoracic Imaging, 21(2):111-122, 2006.

Qiao F., Pan T., Clark J.W., and Mawlawi O. A motion-incorporated reconstruction method for gated PET studies. Phys. Med. Biol., 51:3769-3783, 2006.

Chi P.M., Balter P., Luo D., Mohan R., and Pan T. Relation of external surface to internal tumor motion studied with cine CT. Med. Phys. 33(9):3116-3123, 2006.

Pan T., Mawlawi O., Luo D., Liu H.H., Chi P.M., Mar M.V., Gladish G., Truong M., Erasmus J.J., Liao Z., and Macapinlac H.A. Attenuation correction of PET cardiac data with low-dose average CT in PET/CT, Med. Phys. 33(10):3931-3938, 2006.

Beddar A., Kainz K., Briere T.M., Tsunashima Y., Pan T., Prado K., Mohan R., Gillin M. and Krishnan S. Correlation between internal fiducial tumor motion and external marker motion for liver tumors imaged with 4D-CT, Int. J. Radiat. Oncol. Biol. Phys. 67(2):630-638, 2007.

Qiao F., Pan T., Clark J.W., and Mawlawi O. Region of interest motion compensation for PET image reconstruction, Phys. Med. Biol., 52:2675-2689, 2007.

Liu H., Balter P.,Tutt T., Bum C., Zhang J., Wang C., Chi P., Luo D., Pan T., Hunjan S., Starkschall G., Rosen I., Prado K., Liao Z., Chang J., Komaki R., Cox J.D., Mohan R., and Dong L. Assessing respiration-induced tumor motion and internal target volume using 4DCT for radiation therapy of lung cancer, Int. J. Radiat. Oncol. Biol. Phys. 68:531-540, 2007.

Chi P.M., Mawlawi O., Nehmeh S.A., Erdi Y.E., Balter P.A., Luo D., Mohan R., Pan T. Design of respiration averaged CT for attenuation correction of the PET data from PET/CT. Med. Phys. 34(6), 2039-47, 2007. (cover article of the month)

Abdelnour A.F., Nehmeh S.A., Pan T., Humm J.L., Vernon P., Schoder H, Rosenzweig K.E., Mageras G.S., Yorke E., Larson S.M., and Erdi Y.E. Phase and amplitude binning for 4D-CT imaging, Phys. Med. Biol., 52:3515-3529, 2007.

Gould K.L., Pan T., Loghin C., Johnson N., Guha A. and Sdringola S. Frequent diagnostic errors in cardiac PET-CT due to misregistration of CT attenuation and emission PET images: a definite analysis of causes, consequences and corrections, J. Nuc. Med. 48:1112-1121, 2007. (cover article of the month)

Guerrero T.M., Johnson V., Hart J., Pan T., Khan M., Luo D., Liao Z., Ajani J., and Komaki R. Radiation Pneumonitis: Local dose versus [18F]-Fluorodeoxyglucose uptake response in irradiated lung, Int. J. Radiat. Oncol. Biol. Phys. 68:1030-5, 2007.

Britton K., Starkschall G., Tucker S., Pan T., Nelson C., Chang J., Mohan R., and Komaki R. Assessment of gross tumor volume regression and motion changes during radiation therapy for non-small-cell lung cancer as measured by four-dimensional computed tomography, Int. J. Radiat. Oncol. Biol. Phys. 68:1036-46, 2007.

Lu J., Guerrero T.M., Munro P., Jeung A., Chi P.M., Balter P., Zhu X.R., Mohan R. and Pan T. Four dimensional cone beam CT with adaptive gantry rotation and adaptive data sampling. Med. Phys. 34(9), 3520-3529, 2007.

Starkschall G, Desai N, Balter P, Prado K, Luo D, Cody D, Pan T. Quantitative assessment assurance of four-dimensional computed tomography image acquisition quality. J. Appl. Clin. Med. Phys. 8(3):1-20, 2007.

Pan T, Sun X, and Luo D. Improvement of the cine-CT based 4D-CT imaging. Med. Phys. 34(11), 4499-4503, 2007.

Qiao F., Pan T., Clark J.W., and Mawlawi O. Joint model of motion and anatomy for PET image reconstruction. Med. Phys. 34(12), 4626-4639, 2007.

Bruzzi J.F., Munden R.F., Truong M.T., Marom E.M., Sabloff B.S., Gladish G.W., Iyer R.B., Pan T., Macapinlac H.A., and Erasmus J.J. PET/CT of esophageal cancer: its role in clinical management. RadioGraphics 27(6), 1635-1652, 2007.

Gould K.L. and Pan T. Reply: attenuation correction for stress and rest PET 82Rb myocardial perfusion images. J. Nuc. Med. 48:1913-1914, 2007.

Beddar A., Briere T.M., Balter P., Pan T., Tolani N., Ng C., Szklaruk J. and Krishnan S. 4D-CT imaging with synchronized intravenous contrast injection to improve delineation of liver tumors for treatment planning. Accepted for publication, Radiotherapy and Oncology, 2008.

Gould K.L., Pan T., Loghin C., Johnson N., and Sdringola S. Reducing radiation dose in rest stress cardiac PET-CT by single post stress cine CT for attenuation correction – quantitative validation. Accepted for publication, J. Nuc. Med. 2008.

Program Affiliation:
Program in Medical Physics