The Department of Ophthalmology and Visual Science
Department of Ophthalmology
The Department of Ophthalmology

Faculty Biography


Dr. Steven Wang


Clinical and Research Interests:

  1. Genetic components and molecular mechanisms that harness retinal ganglion cell formation - from specification to terminal differentiation.
  2. Molecular mechanisms that regulate bipolar cell formation.
  3. Molecular mechanisms and cellular aspects of retinal stem cell retention.
  4. Wiring plasticity during retina development.

Publications (selected):

  1. Bin Lin, Wang, S. W., and Masland, R. H. (2004). Retinal ganglion cell type, size and tiling can be specified independent of homotypic dendritic contacts. Neuron 43, 475-485.
  2. Ohtoshi, A., Wang, S. W., Maeda, H., Sazik, S. M., Frishman, L. J., Klein, W. H., and Behringer, R. (2004). Regulation of retinal cone bipolar cell differentiation and photopic vision by the CVC homeobox gene Vsx1. Current Biology 14, 530-536.
  3. Wang, S. W., Mu, X., Bowers, W. J., Kim, D.-S., Plas, D. J., Crair, M. C., Gan, L., Federoff, H. J., and Klein, W. H. (2002). Brn3b/Brn3c double knockout mice reveal an unsuspected role for Brn3c in retinal ganglion cell axon outgrowth. Development 129, 467-477.
  4. Wang, S. W., Mu, X., Bowers, W. J., and Klein, W. H. (2002). Retinal ganglion cell differentiation in cultured mouse retinal explants. Methods 28, 448-456.
  5. Mu, X., Zhao, S., Pershad, R., Hsieh, Z.-F., Scarpa, A., Wang, S. W., White, R. A., Beremand, P. D., Thomas, T. L., Gan, L., Klein., W. H. (2001). Gene expression in the developing mouse retina by EST sequencing and microarray analysis. Nucleic Acids Research 29, 4983-4993.
  6. Wang, S. W., Kim, B.-S., Ding, K., Wang, H., Sun, D., Johnson, R. L., Klein, W. H. (2001). Requirement for math5 in the development of retinal ganglion cells. Genes & Development 15, 24-29.
  7. Wang, S. W., Gan, L., Martin, S. E., Klein, W. H. (2000). Abnormal polarization and axon outgrowth in retinal ganglion cells lacking the POU-domain transcription factor brn-3b. Mol. & Cell. Neurosci. 16, 141-156. (Cover)
  8. Gan, L., Wang, S. W., Huang, Z., and Klein, W. H. (1999). POU domain factor Brn-3b is essential for retinal ganglion cell differentiation and survival but not for initial cell fate specification or migration. Developmental Biology 210, 469-480.
  9. Wang, S. W., Griffin, F. J., and Clark, W. H. (1997). Cell-cell association directed spindle orientation in the early development of the marine shrimp Sicyonia ingentis. Development 124, 773-780. (Cover)
  10. Bihn, E. A., Paul, A.-L., Wang, S. W., Erdos, G. W., and Ferl, R. J. (1997). Localization of 14-3-3 proteins in the nuclei of arabidopsis and maize. The Plant Journal 12, 1439-1445.
  11. Hertzler, P. L., Wang, S. W., and Clark, W. H., Jr. (1994). Mesendoderm cell and archenteron formation in isolated blastomeres from the shrimp Sicyonia ingentis. Developmental Biology 164, 333-344.
  12. Hwang, P. P. and Wang, S. W. (1993). Immunoelectron microscopical study of prolactin in pituitary of tilapia (Orochromis mossambicus.) Acta Histochem. Cytochem. 26, 203-211.
  13. Shen, S. C. and Wang, S. W. (1991). Systematic revision of codlet (Bregmacerotidae) with designations of the neotypes for Bregmaceros pescadorus and Bregmaceros lanceolatus. Bulletin of Institute of Zoology, Academia Sinica, Taipei 30, 63-71.
  14. Wang, S. W., Mao, C.-A., Pang P., and Klein, W. H. (2006). Brn3a and Brn3b POU domain transcription factors have distinct functions in retinal ganglion cell neurite formation. (in preparation)
  15. Chen, Y.-C., Tagawa, K., and Wang, S.W. (2006). Connection plasticity resides in cone bipolar cells during retina development. (in preparation)
  16. Gupta, M., Chen, Y.-C., Tagawa, K., Liu, W., and Wang, S.W. (2006). ZFH, a novel factor under the control of Math5 for retinal ganglion cell formation. (in preparation)


Faculty Biography

Dr. Steven Wang
  • Dr. Steven Wang
  • Department of Ophthalmology
  • University of Texas-Houston Medical School
    6431 Fannin Street, MSB-7.024
    Houston, Texas 77030
  • phone: (713) 500-5995
Pub Med