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Anti-DSP Monoclonal Antibody, 2G7.3

The Technology: Researchers at the University of Texas Health Science Center at Houston (UTHSC-H) have developed methods and compositions to detect, isolate and characterize the very acidic, high molecular weight dentin sialoprotein (DSP). DSP is a glycoprotein accounting for 5–8% of the dentin non-collagenous proteins. The inventors have created a monoclonal anti-DSP antibody that can identify native DSP in fractions of incisor dentin extracted from rats. This technology will be useful as a tool to further investigate the characteristics of DSP.

Publications:
• Qin C, Brunn JC, Baba O, Wygant JN, McIntyre BW, Butler WT. Dentin sialoprotein isoforms: detection and characterization of a high molecular weight dentin sialoprotein. Eur J Oral Sci. 2003 Jun;111(3):235-42.
• Baba O, Qin C, Brunn JC, Jones JE, Wygant JN, McIntyre BW, Butler WT. Detection of dentin sialoprotein in rat periodontium. Eur J Oral Sci. 2004 Apr;112(2):163-70.
• Qin C, Brunn JC, Cadena E, Ridall A, Butler WT. Dentin sialoprotein in bone and dentin sialophosphoprotein gene expressed by osteoblasts. Connect Tissue Res. 2003;44 Suppl 1:179-83.
• Butler WT, Brunn JC, Qin C, McKee MD. Extracellular matrix proteins and the dynamics of dentin formation. Connect Tissue Res. 2002;43(2-3):301-7.

UTHSC-H Ref. No.: 2006-0038 RMD
Inventors: Qin
Patent Status: N/A
License Available: worldwide; non-exclusive, exclusive

Download Summary (2006-0038)