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Anti-NEDD8 Monoclonal Antibody

The Technology: A researcher at the University of Texas Health Science Center at Houston (UTHSC-H) has developed a monoclonal antibody to NEDD8. NEDD8 is a ubiquitin-like protein that controls vital biological events through its conjugation to cullin family members. Cellular expression of NEDD8 can be determined via the monoclonal NEDD8 antibody. This antibody will be useful in determining how NEDD8 is regulated and tracking the interaction between the NEDD8 conjugation system and the proteasomal degradation pathway.

Publications:
• Kamitani T, Katsumi K, Nguyen R, Yeh ETH (1997) Characterization of NEDD8, a developmentally down-regulated ubiquitin-like molecule. J Biol Chem 272:28557-28562.
• Gong L, Yeh ETH (1999) Identification of the activating and conjugating enzymes of the NEDD8-conjugation pathway. J Biol Chem 274:12036-12042.
• Kamitani T, Kito K, Fukuda-Kamitani T, Yeh ETH (2001) Targeting of NEDD8 and its conjugates for proteasomal degradation by Nub1. J Biol Chem 276:46655-46660.
• Tanaka, T., Kawashima, H., Yeh, E.T.H., Kamitani, T. Regulation of NEDD8 conjugation system by a splicing variant, NUB1L. J Biol Chem 278:32905-32913, 2003.

UTHSC-H Ref. No.: 1996-0012RMD
Inventors: Edward Yeh
Patent Status: N/A
License Available: world-wide; non-exclusive

Download Summary (1996-0012)