ANTIPEPTIDE ANTIBODIES THAT RECOGNIZE SPECIFIC SOMATOSTATIN RECEPTOR SUBTYPES

 

The Technology:  This patent covers:

1. A method for developing somatostatin receptor subtype specific antibodies.
2. Antibodies developed using this method to identify somatostatin receptor subtypes belonging to the seven transmembrane domain receptor family.
3. The use of these antibodies, alone or in kit form, to identify somatostatin receptors in tissues or protein extracts.

The utility of the patented technology is founded upon its ability to selectively identify somatostatin receptor subtypes and thus will be of great value, but not limited to, the fields of diabetes, immunology, neurology and oncology.

Publications :  

• Development and use of a receptor antibody to characterize the interaction between somatostatin receptor sst1 and G proteins. Mol Pharmacol. 1995 Dec;48(6):1004-14
• Localization of the stomatostatin receptor sst2A in rat brain using a specific anti peptide antibody. J Neurosci. 1996 Jul 15;16(14):4468-78.
• Coupling specificity between somatostatin receptor sst2A and G proteins: Isolation of the receptor-G protein complex with a receptor antibody.  Mol Endocrinol. 1997 May;11(5):527-37.
• Agonist induced desensitization, internalization and phosphorylation of the sst2A somatostatin receptor.  J Biol Chem. 1997 May 23;272(21):13869-76.
• Immunohistochemical localization of somatostatin receptor sst2A in the rat pancreas.  Endocrinology. 1997 Jul;138(7):2632-5. (chosen as cover illustration for the June 1997 issue).
• Cell specific expression of the sst2A and sst5 somatostatin receptors in the rat anterior pituitary. Endocrinology. 1998 Jan;139(1):414-9.
• Interrelationships between somatostatin sst2A receptors and somatostatin-containing axons in rat brain: evidence for regulation of cell surface receptors by endogenous somatostatin.  J Neurosci. 1998 Feb 1;18(3):1056-71.
• Immunohistochemical localization of somatostatin receptor sst2A in human tumors.  Am J Pathol. 1998 Jul;153(1):233-45.
• Immunohistochemical localization of somatostatin receptor sst2A in human pancreatic islets. J Clin Endocrinol Metab. 1998 Oct;83(10):3746-9.
• Immunohistochemical localization of somatostatin receptor sst2A in human rheumatoid synovium. J Rheumatol. 1999 Mar;26(3):532-5.
• Immunohistochemical detection of somatostatin receptor subtypes sst1 and sst2A in human somatostatin receptor positive tumors.  J Clin Endocrinol Metab. 1999 Feb;84(2):775-80.
• Colocalization of somatostatin receptor sst5 and insulin in the rat pancreatic ß-cells.  Endocrinology. 1999 Aug;140(8):3790-6.
• Immunohistochemical localisation of somatostatin receptor sst2A in sarcoid granulomas.  Eur J Clin Invest. 1999 Jul;29(7):630-6
• Pituitary somatostatin receptor sst1-5 expression during rat development: Age - dependent expression of sst2.  Endocrinology. 1999 Oct;140(10):4739-44.

 

NON-CONFIDENTIAL TECHNOLOGY DESCRIPTION

The preceding is intended to be a non-confidential summary of a novel technology created at the University of Texas Health Science center at Houston.

UTHSCH Ref. No.

Inventors: Dr. Agnes Schonbronn

Patent Status: United States Patent Application 05/998,154

License Available: world-wide; exclusive or non-exclusive

 

To obtain further information about this technology, please contact:
Office of Technology Management, 7000 Fannin, Suite 720, Houston, TX 77030
Phone: (713) 500-3369  Fax: (713) 500-0331
Email: uthsch-otm@uth.tmc.edu