PARIS-4 FOR THE PREVENTION AND TREATMENT OF RESTENOSIS

 

 Market:  Each year there are at least one million angioplasty procedures performed in North America alone. Nearly eighty percent of these procedures use drug eluting stents, which have been a useful innovation for the prevention of restenosis.  However, these drug-eluting stents may not be effective in patients with diabetes and small arteries.  In addition, the stents require patients to be maintained on very long-term anti-platelet therapy using an expensive anti-platelet medication which, may lead to bleeding complications.  Drug-eluting stents also have the potential to elicit an inflammatory reaction in the vascular wall.   Therefore, a need, and a market, still exists for additional innovations for the prevention of restenosis based on different principles and strategies.

 

The Technology:  The inventors have identified and validated PARIS-4 as a protein that prevents restenosis by a mechanism of inhibiting smooth muscle cell proliferation and migration. PARIS-4, the chemokine and mucin-stalk portion of fractalkine, represents a novel approach to treating and preventing restenosis.  PARIS-4 can be administered parenterally (either intravenously or subcutaneously) during the periprocedural period of percutaneous coronary interventions.  In addition, PARIS-4, a native molecule with significantly less immunogenicity than chemical compounds currently used in drug-eluting stents, may be eluted from stents coated with PARIS-4. 

 

NON-CONFIDENTIAL TECHNOLOGY DESCRIPTION

The preceding is intended to be a non-confidential summary of a novel technology created at the University of Texas Health Science center at Houston (UTHSCH), for which the University has obtained patent protection. 

UTHSCH Ref. No. 2003-0047

Inventors: Drs. Fujise and Mnjoyan

Patent Status: Pending

License Available: world-wide; exclusive or non-exclusive

 

To obtain further information about this technology, please contact:
Office of Technology Management, 7000 Fannin, Suite 720, Houston, TX 77030
Phone: (713) 500-3369  Fax: (713) 500-0331
Email: uthsch-otm@uth.tmc.edu