Molecular Basis of Microbial Pathogenesis
Course Description / Assignments
GS07 0092
Course Description / Presentation Assignments
MicPath Articles - January
MicPath Articles - February
MicPath Articles - March
Faculty
If you have trouble with obtaining the .pdf file via the link, please contact Dr. Norris at Steven.J.Norris@uth.tmc.edu.)
THE SPECTRUM OF HOST-MICROBE INTERACTIONS: WHAT IS A PATHOGEN?
Steven J. Norris, Ph.D.
Tuesday, 1/8/2008: What is a pathogen? (Norris)
Article: Marcy, Y., et al. 2007. Dissecting biological "dark matter" with single-cell genetic analysis of rare and uncultivated TM7 microbes from the human mouth. Proc. Natl. Acad. Sci. USA 104: 11889-11894. Link
Related review: Bentley, D. R. 2006. Whole-genome re-sequencing. Current Opinion in Genetics & Development 16: 545-552. Link
EUKARYOTIC PATHOGENESIS
Michael C. Lorenz, Ph.D.
Thursday, 1/10/2008: How to write a grant and Intro to Eukaryotic Pathogenesis (Lorenz)
Article: Verstrepen, et al. (2005) Intragenic tandem repeats generate functional variability. Nat. Genet. 37:986. Link
Tuesday, 1/15/2008: (Student presentation)
Article: Domergue, et al. (2005) Nicotinic acid limitation regulates silencing of Candida glabrata adhesins during UTI. Science 308:866. Link
Please also read the supplemental material at http://www.sciencemag.org/cgi/data/1108640/DC1/1
Introductory review: Kaur, et al. (2005) A yeast by any other name: Candida glabrata and its interaction with the host. Curr. Opin. Micro. 8:378. Link
Thursday, 1/17/2008: (Student presentation)
Article: Phan, et al. (2007) ALS3 is a Candida albicans invasin that binds to cadherins and induces endocytosis by host cells. PLoS Biol. 5:e64. Link
Introductory review: Filler (2006) Candida–host cell receptor–ligand interactions. Curr. Opin. Micro. 9:333. Link
Tuesday, 1/22/2008: (Student presentation)
Article: Frank, et al. (2007) Variable switching rates of malaria virulence genes are associated with chromosomal position. Mol. Micro. 64:1486. Link
Introductory review: Ralph and Scherf (2005) The epigenetic control of antigenic variation in Plasmodium falciparum. Curr. Opin. Micro. 8:434. Link
Thursday, 1/24/2008: (Student presentation)
Article: Gruszynski, et al. (2006) Regulation of surface coat exchange by differentiating African trypanosomes. Mol. Biochem. Parasitol. 147:211. Link
Introductory review: Taylor and Rudenko (2006) Switching trypanosome coats: what's in the wardrobe? Trends Genet. 22:614. Link
BACTERIAL ADHESINS / INTRACELLULARITY
Magnus Höök, Ph.D. and Yi Xu, Ph.D.
Tuesday, 1/29/2008: Introduction (Drs. Höök and Xu)
Article: Kang et al. (2007) Stabilizing isopeptide bonds revealed in Gram-positive bacterial pilus structure. Science 318: 1625-1628. PDF
Useful review: Pizarro-Cerda, J. and P. Cossart. 2006. Bacterial Adhesion and Entry into Host Cells. Cell 124:715-727. PDF
Thursday, 1/31/2008 (Student presentation)
Article: Wang et al. (2006) Streptococcal modulation of cellular invasion via TGF-beta1 signaling. PNAS 103: 2380-2385. PDF
Useful review: Nitsche-Schmitz et al. (2007) Invasion mechanisms of gram-positive pathogenic cocci. Thromb. Haemost. 98: 488-496. PDF
