Molecular Basis of Microbial Pathogenesis
Course Description / Assignments
GS07 0092
Course Description / Presentation Assignments
MicPath Articles - January
MicPath Articles - February
MicPath Articles - March
Faculty
If you have trouble with obtaining the .pdf file via the link, please contact Dr. Norris at Steven.J.Norris@uth.tmc.edu.)
BACTERIAL ADHESINS / INTRACELLULARITY, ctd.
Magnus Höök, Ph.D. and Yi Xu, Ph.D.
Tuesday, 2/5/2008 (Student presentation)
Article: Ton-That, H. and O. Schneewind. (2003) Assembly of pili on the surface of Corynebacterium diphtheriae, Molec. Microbiol. 50: 1429-1438. PDF
Useful review: Mandlik A. et al. Pili in Gram-positive bacteria: assembly, involvement in colonization and biofilm development. Trends Microbiol. 16: 33-40. PDF
Thursday, 2/7/2008 (Student presentation)
Jayachandran et al. (2007) Survival of mycobacteria in macrophages is mediated by coronin 1-dependent activation of calcineurin. Cell 130: 37-50. PDF
Useful review: Trimble, W. S. and S. Grinstein. 2007. TB or not TB: Calcium regulation in mycobacterial survival. Cell 130: 12. PDF
Tuesday, 2/12/2008 (Student presentation)
Ponnuraj K. et al. 2003. A 'dock, lock and latch' structural model for a staphylococcal adhesin binding to fibrinogen. Cell 115: 217-228. PDF
Useful review: Rivera et al. (2007) Fibronectin-binding proteins of gram-positive bacteria. Thromb. Haemost. 98: 503-511. PDF
Thursday 2/14/2008 and Tuesday 2/19/2008 – Student presentations of Mini-Grant specific aims (in MMG Library, MSB 1.180)
Model Hosts to Identify Virulence Factors and Immune Responses
Danielle A. Garsin, Ph.D.
Thursday, 2/21/2008. Identifying Virulence Factors using a Model Host (student presentation)
Assigned Article:
Tenor, J. L., B. A. McCormick, F. M. Ausubel, and A. Aballay. 2004. Caenorhabditis elegans-Based Screen Identifies Salmonella Virulence Factors Required for Conserved Host-Pathogen Interactions. Current Biology 14:1018-1024. Link
Useful Review:
Schulenburg, H., C. L. Kurz, and J. J. Ewbank. 2004. Evolution of the innate immune system: the worm perspective. Immunol Rev 198:36-58. Link
Tuesday, 2/26/ 2008. Developing a Model Host System (student presentation)
Assigned Article:
Jha, A. K., H. P. Bais, and J. M. Vivanco. 2004. Enterococcus faecalis Mammalian Virulence-Related Factors Exhibit Potent Pathogenicity in the Arabidopsis thaliana Plant Model. Infection and Immunity 73:464-475. Link
Useful Book Chapter (in MMG Library):
Gilmore, M. S., P. S. Coburn, S. R. Nallapareddy, and B. E. Murray. 2002. Enterococcal Virulence in The Enterococci: Pathogenesis, Molecular Biology, and Antibiotic Resistance, M.S. Gilmore, Editor. 2002, ASM Press: Washington, DC. p. 316-325.
Thursday 2/28/2008. Identifying Immune Responses Using Model Hosts I (student presentation)
Assigned Article:
Tenor, J. L., A. Aballay. 2008. A conserved Toll-like receptor is required for Caenorhabditis elegans innate immunity. EMBO Rep. 9:103-109. Link
Useful Review:
Nicholas, H. R., and J. Hodgkin. 2004. Responses to infection and possible recognition strategies in the innate immune system of Caenorhabditis elegans. Mol Immunol 41:479-93. Link
