Molecular Basis of Microbial Pathogenesis
Course Description / Assignments
GS07 0092
Course Description / Presentation Assignments
MicPath Articles - January
MicPath Articles - February
MicPath Articles - March
Faculty
If you have trouble with obtaining the .pdf file via the link, please contact Dr. Norris at Steven.J.Norris@uth.tmc.edu.)
Model Hosts to Identify Virulence Factors and Immune Responses (ctd.)
Danielle A. Garsin, Ph.D.
Tuesday, 3/4/2008. Identifying Immune Responses Using Model Hosts II (student presentation)
Assigned Article:
Ha, E. M., C. T. Oh, Y. S. Bae, W. J. Lee. 2005. A Direct Role for Dual Oxidase in Drosophilia Gut Immunity. Science. 310: 847-850. Link
Groundwork Paper
Ha, E. M., C. T. Oh, J. H. Ryu, Y. S. Bae, S. W. Kang, I. H. Jang, P. T. Brey, W. J. Lee. 2005. An antioxidant system required for host protection against gut infection in Drosophila. Developmental Cell. 18: 125-132. Link
SECRETION SYSTEMS IN PATHOGENESIS
Peter J. Christie, Ph.D.
Thursday, 3/6/2008
Assigned Article
Mouratou B, Schaeffer F, Guilvout I, Tello-Manigne D, Pugsley AP, Alzari PM, Pecorari F. 2007. Remodeling a DNA-binding protein as a specific in vivo inhibitor of bacterial secretin PulD. Proc Natl Acad Sci U S A. 104:17983-8. PDF
Review
Johnson TL, Abendroth J, Hol WG, Sandkvist M. 2006 Type II secretion: from structure to function. FEMS Microbiol Lett. 255:175-86. PDF
Tuesday, 3/18/08
Assigned Article
Jaumouille, V., Francetic, O., Sansonetti, P.J., Nhieu, G.T.V. 2008. Cytoplasmic targeting of IpaC to the bacterial pole directs polar type III secretion in Shigella EMBO J. 27: 447–457. PDF
Review
Ogawa, M., Handa, Y., Ashida, H., Suzuki, M., and C. Sasakawa 2008. The versatility of Shigella effectors Nature Reviews Microbiology 6:11-15. PDF
Thursday, 3/20/08
Assigned Article
Saenz HL, Engel P, Stoeckli MC, Lanz C, Raddatz G, Vayssier-Taussat M, Birtles R, Schuster SC, Dehio C. 2007. Genomic analysis of Bartonella identifies type IV secretion systems as host adaptability factors. Nat Genet. 39:1469-76. PDF
Review
Schmid MC, Scheidegger F, Dehio M, Balmelle-Devaux N, Schulein R, Guye P, Chennakesava CS, Biedermann B, Dehio C. 2006. A translocated bacterial protein protects vascular endothelial cells from apoptosis. PLoS Pathog. 2:115. PDF
Tuesday, 3/25/08
Assigned Article
Pukatzki S, Ma AT, Revel AT, Sturtevant D, Mekalanos JJ. 2007. Type VI secretion system translocates a phage tail spike-like protein into target cells where it cross-links actin. Proc Natl Acad Sci U S A. 104:15508-13. PDF
Reviews
Bingle LE, Bailey CM, Pallen MJ. Type VI secretion: a beginner's guide. Curr Opin Microbiol. 2008 Feb 18 [Epub ahead of print] Link
Yahr TL. 2006. A critical new pathway for toxin secretion? N Engl J Med. 355:1171-2. PDF
Thursday, 3/27/08
Assigned Article
McLaughlin B, Chon JS, MacGurn JA, Carlsson F, Cheng TL, Cox JS, Brown EJ. 2007. A mycobacterium ESX-1-secreted virulence factor with unique requirements for export. PLoS Pathog. 3: 1051-1061. PDF
Review
Abdallah AM, Gey van Pittius NC, Champion PA, Cox J, Luirink J, Vandenbroucke-Grauls CM, Appelmelk BJ, Bitter W. 2007. Type VII secretion--mycobacteria show the way. Nat Rev Microbiol. 5: 883-91. PDF
