Molecular Basis of Microbial Pathogenesis

MicPath Articles - February

 

February 3                                                                                                                       Klauer

Type III secretion

 Assigned Article:

Navarro L, Jay F, Nomura K, He SY, Voinnet O.  Suppression of the microRNA pathway by bacterial effector proteins.  Science. 2008 Aug 15;321(5891):964-7.  Link  (see also Online Supplementary Material)

Introductory Review:

Stavrinides J, McCann HC, Guttman DS.  Host-pathogen interplay and the evolution of bacterial effectors.  Cell Microbiol. 2008 Feb;10(2):285-92. Epub 2007 Nov 21. Review.  Link

 

February 5                                                                                                                     Schoberle

Type IV secretion

 Assigned Article:

Pan X, Lührmann A, Satoh A, Laskowski-Arce MA, Roy CR. Ankyrin repeat proteins comprise a diverse family of bacterial type IV effectors.  Science. 2008 Jun 20;320(5883):1651-4.  Link

Introductory Review:

Isberg RR, O'Connor TJ, Heidtman M.  The Legionella pneumophila replication vacuole: making a cosy niche inside host cells.  Nat Rev Microbiol. 2009 Jan;7(1):13-24. Epub 2008 Nov 17. Review.  Link

 

 February 10                                                                                                                   ALL

Secretion Inhibitors

 Assigned Articles:

Felise HB, Nguyen HV, Pfuetzner RA, Barry KC, Jackson SR, Blanc MP, Bronstein PA, Kline T, Miller SI.  An inhibitor of gram-negative bacterial virulence protein secretion.  Cell Host Microbe. 2008 Oct 16;4(4):325-36.  Link   (see also Online Supplementary Material)

 

Filutowicz M, Burgess R, Gamelli RL, Heinemann JA, Kurenbach B, Rakowski SA, Shankar R.  Bacterial conjugation-based antimicrobial agents.  Plasmid. 2008 Jul;60(1):38-44. Epub 2008 May 14. Review.  Link

 

February 12                             (Faculty approval of aims)                                     Abrams

Type VI Secretion

 Assigned Article:

Bönemann G, Pietrosiuk A, Diemand A, Zentgraf H, Mogk A.  Remodelling of VipA/VipB tubules by ClpV-mediated threading is crucial for type VI protein secretion.  EMBO J. 2009 Jan 8. [Epub ahead of print]  Link

 Introductory Review:

Cascales E.  The type VI secretion toolkit.  EMBO Rep. 2008 Aug;9(8):735-41. Epub 2008 Jul 11. Review.  Link

 

February 17                                                                                                                  Bordt                 

Type VII Secretion

 Assigned Article:

Raghavan S, Manzanillo P, Chan K, Dovey C, Cox JS. Secreted transcription factor controls Mycobacterium tuberculosis virulence.  Nature. 2008 Aug 7;454(7205):717-21.  Link

 Introductory Review:

Atmakuri K, Fortune SM. Regulation of protein secretion by ... protein secretion?  Cell Host Microbe. 2008 Sep 11;4(3):190-1.  Link

 

Identifying Virulence Factors using a Model Host

(Dr. Garsin)

Thursday, February 26, 2009. 

Assigned Article:

Tenor, J. L., B. A. McCormick, F. M. Ausubel, and A. Aballay. 2004. Caenorhabditis elegans-Based Screen Identifies Salmonella Virulence Factors Required for Conserved Host-Pathogen Interactions. Current Biology 14:1018-1024.  Link

Useful Review:

Schulenburg, H., C. L. Kurz, and J. J. Ewbank. 2004. Evolution of the innate immune system: the worm perspective. Immunol Rev 198:36-58.  Link

Under construction

If you have trouble with obtaining the .pdf file via the link, please contact Dr. Norris at Steven.J.Norris@uth.tmc.edu.)