Molecular Basis of Microbial Pathogenesis

MicPath Articles - April

 

Bacterial Effector Protein Interactions 

(Drs. Xu and Hook)

Thursday, April 2, 2009. 

Assigned Article:

Bestebroer, J., M. J. Poppelier, L. H. Ulfman, P. J. Lenting, C. V. Denis, K. P. van Kessel, J. A. van Strijp, and C. J. de Haas. 2007. Staphylococcal superantigen-like 5 binds PSGL-1 and inhibits P-selectin-mediated neutrophil rolling. Blood 109:2936-43. Link

 

Hijacking of the Ubiquitin Pathway by Bacterial Pathogens  

(Dr. Theresa M. Koehler)

Reviews applicable to this entire section:

Aurélie Angot, Annette Vergunst, Stéphane Genin, and Nemo Peeters. Exploitation of eukaryotic ubiquitin signaling pathways by effectors translocated by bacterial type III and type IV secretion systems. PLoS Pathog. 2007 January 3(1), PMID 1781473.  Link

Anne Rytkonen and David W. Holden. Bacterial interference of ubiquitination and deubiquitination. Cell Host Microbe 2007 1(1):13-22. Link

 

Tuesday, April 7, 2009.

Assigned Article:

Robert B. Abramovitch, Radmila Janjusevic, C. Erec Stebbins, and Gregory B. Martin. Type III effector AvrPtoB requires intrinsic E3 ubiquitin ligase activity to suppress plant cell death and immunity. Proc. Natl. Acad. Sci. U S A. 2006 February 21; 103(8): 2851–2856. PMID: 1413779  Link

 

Thursday, April 9, 2009.

Assigned Article:

Aurélie Angot, Nemo Peeters, Esther Lechner, Fabienne Vailleau, Catherine Baud, Laurent Gentzbittel, Elodie Sartorel,Pascal Genschik, Christian Boucher, and Stéphane Genin. Ralstonia solanacearum requires F-box-like domain-containing type III effectors to promote disease on several host plants. Proc. Natl. Acad. Sci. 2006 103(39):14620-14625. PMID: 1600009  Link

 

Tuesday, April 14, 2009.

Assigned Article:

Kubori, T., Hyakutake, A., Nagai, H. Legionella translocates an E3 ubiquitin ligase that has multiple U-boxes with distinct functions. Mol. Microbiol. 2008. 67(6):1307-19. PMID: 18284575 Link

 

Thursday, April 16, 2009.

Assigned Article:

Cindy M. Quezada, Stuart W. Hicks, Jorge E. Galán, and C. Erec Stebbins. A family of Salmonella virulence factors functions as a distinct class of autoregulated E3 ubiquitin ligases. Proc. Natl. Acad. Sci. 2009 106(12):4864-4869. PMID: 2653562.  Link

ANTIGENIC VARIATION

Steven J. Norris, Ph.D.

Tuesday, 4/21/2009

Assigned article
Liu, C. H., S. M. Lee, J. M. VanLare, D. L. Kasper, and S. K. Mazmanian. 2008. Regulation of surface architecture by symbiotic bacteria mediates host colonization. Proc. Natl. Acad. Sci. U.S.A. 105:3951-3956. 
Link

Related article
Coyne, M. J., K. G. Weinacht, C. M. Krinos, and L. E. Comstock. 2003. Mpi recombinase globally modulates the surface architecture of a human commensal bacterium. Proc. Natl. Acad. Sci. U.S.A.100:10446-51.  Link

Thursday, 4/23/2009

Assigned article
Dai, Q., B. I. Restrepo, S. F. Porcella, S. J. Raffel, T. G. Schwan, and A. G. Barbour. 2006. Antigenic variation by Borrelia hermsii occurs through recombination between extragenic repetitive elements on linear plasmids. Mol. Microbiol. 60:1329-43.  Link

Related review:
Norris, S. J. 2006. Antigenic variation with a twist - the Borrelia story. Mol. Microbiol. 60:1319-22.  Link

HOST PROTEIN EXPRESSION IN PATHOGENESIS

Tuesday, 4/28/2009

Assigned article
Corbin, B. D., E. H. Seeley, A. Raab, J. Feldmann, M. R. Miller, V. J. Torres, K. L. Anderson, B. M. Dattilo, P. M. Dunman, R. Gerads, R. M. Caprioli, W. Nacken, W. J. Chazin, and E. P. Skaar. 2008. Metal chelation and inhibition of bacterial growth in tissue abscesses. Science 319:962-965.  Link

Related review
Cornett, D. S., M. L. Reyzer, P. Chaurand, and R. M. Caprioli. 2007. MALDI imaging mass spectrometry: molecular snapshots of biochemical systems. Nat. Meth. 4:828-833. Link

Thursday, 4/30/2009

Assigned article
Brass, A. L., D. M. Dykxhoorn, Y. Benita, N. Yan, A. Engelman, R. J. Xavier, J. Lieberman, and S. J. Elledge. 2008. Identification of host proteins required for HIV infection through a functional genomic screen. Science 319:921-926.  Link

Related review
Rossi, J. J., C. H. June, and D. B. Kohn. 2007. Genetic therapies against HIV. Nat. Biotech. 25:1444-1454. Link

Under construction

If you have trouble with obtaining the .pdf file via the link, please contact Dr. Norris at Steven.J.Norris@uth.tmc.edu.)