Molecular Basis of Microbial Pathogenesis - 2011

MicPath Articles - January

Note: It may be necessary to log in to the HAM-TMC Library website to acquire some of the articles.

Introduction

(Dr. Koehler)

Tuesday, Jan. 11 Grant Writing Guidelines

 

The human microbiota - what's normal and what's pathogenic?

(Dr. Norris)

Thursday, January 13
Assigned article
Qin, J., et al. 2010. A human gut microbial gene catalogue established by metagenomic sequencing. Nature 464:59-65.  Link

 

Model Hosts as Tools

(Dr. Garsin)

Tuesday, Jan. 18  Identifying Antimicrobials Using Model Hosts

Assigned article

Moy, T. I., A. R. Ball, Z. Anklesaria, G. Casadei, K. Lewis, F. M. Ausubel. 2006.  Identification of Novel Antimicrobials Using a Live-Animal Infection Model.  Proc Natl Acad Sci U S A. 103:10414-10419. Link

 

Thursday, Jan. 20  Identifying Microbial Interactions Using a Model Host

Assigned article

Peleg, A. Y., E. Tampakakis, B. B. Fuchs, G. M. Eliopoulos, R. C. Moellering and E. Mylonakis. 2008. Prokaryote-Eukaryote Interactions Identified by Using Caenorhabditis elegans. Proc Natl Acad Sci U S A. 105:14585-14590.  Link

Useful Review:

Peleg, A. Y., D. A. Hogan and E. Mylonakis. 2010. Medically Important Bacterial-Fungal Interactions. Nature Reviews Microbiology. 8:340-349. Link

 

Tuesday, Jan. 25  Identifying Immune Responses Using a Model Host

Assigned articles

Styer, K. L., V. Singh, E. Macosko, S. E. Steele, C. I. Bargmann, A. Aballay. 2008. Innate Immunity is Regulated by Neurons Expressing NPR-1/GPCR. Science. 322:460-64. Link

Reddy, K. C., E. C. Andersen, L. Kruglyak, D. H. Kim. 2009. A Polymorphism in npr-1 is a Behavioral Determinant of Pathogen Susceptibility in C. elegans. Science. 323:382-84. Link

 

Modulation of host cellular response by protozoan parasites

(Dr. Li)

Thursday, Jan. 27

Assigned article:

Taylor S, Barragan A, Su C, Fux B, Fentress SJ, Tang K, Beatty WL, Hajj HE, Jerome M, Behnke MS, White M, Wootton JC, Sibley LD. A secreted serine-threonine kinase determines virulence in the eukaryotic pathogen Toxoplasma gondii. Science. 2006 Dec 15;314(5806):1776-80. Link

Useful review:

Bradley PJ, Sibley LD. Rhoptries: an arsenal of secreted virulence factors. Curr Opin Microbiol. 2007 Dec;10(6):582-7.  Link

 

If you have trouble with obtaining the .pdf file via the link, please contact Dr. Norris at Steven.J.Norris@uth.tmc.edu.)