Molecular Basis of Microbial Pathogenesis - 2011

MicPath Articles - February

Note: It may be necessary to log in to the HAM-TMC Library website to acquire some of the articles.

Parasite Pathogenesis , ctd.

(Dr. Li)

Tuesday, Feb. 1

Assigned article

Saeij JP, Boyle JP, Coller S, Taylor S, Sibley LD, Brooke-Powell ET, Ajioka JW, Boothroyd JC.(2006) Polymorphic secreted kinases are key virulence factors in toxoplasmosis. Science. 2006 Dec 15;314(5806):1780-3.  Link

 

Thursday, Feb. 3

Assigned article

Saeij JP, Coller S, Boyle JP, Jerome ME, White MW, Boothroyd JC. Toxoplasma co-opts host gene expression by injection of a polymorphic kinase homologue. Nature. 2007 Jan 18;445(7125):324-7. Link

 

Tuesday, Feb. 8.

Assigned articles

Steinfeldt T, Könen-Waisman S, Tong L, Pawlowski N, Lamkemeyer T, Sibley LD, Hunn JP, Howard JC. Phosphorylation of Mouse Immunity-Related GTPase (IRG) Resistance Proteins Is an Evasion Strategy for Virulent Toxoplasma gondii. PLoS Biol. 2010 Dec 21;8(12):e1000576 Link

Fentress SJ, Behnke MS, Dunay IR, Mashayekhi M, Rommereim LM, Fox BA, Bzik DJ, Taylor GA, Turk BE, Lichti CF, Townsend RR, Qiu W, Hui R, Beatty WL, Sibley LD.  Phosphorylation of immunity-related GTPases by a Toxoplasma gondii-secreted kinase promotes macrophage survival and virulence. Cell Host Microbe. 2010 Dec 16;8(6):484-95  Link

Useful review

Feng CG, Sher A.  Parasites paralyze cellular host defense system to promote virulence. Cell Host Microbe. 2010 Dec 16;8(6):463-4.  Link

 

Bacterial Secretion Mechanisms

(Dr. Christie)

Feb. 10  Nobles

Assigned article

Akopyan K, Edgren T, Wang-Edgren H, Rosqvist R, Fahlgren A, Wolf-Watz H, Fallman M.  From the Cover: Translocation of surface-localized effectors in type III secretion. Proc Natl Acad Sci U S A. 2011 Jan 25;108(4):1639-44. Link  Supplement

Useful review

Hayes CS, Aoki SK, Low DA.  Bacterial contact-dependent delivery systems.  Annu Rev Genet. 2010;44:71-90.  Link

 

Feb 15  Bakhru

Assigned article

Niu H, Kozjak-Pavlovic V, Rudel T, Rikihisa Y.  Anaplasma phagocytophilum Ats-1 is imported into host cell mitochondria and interferes with apoptosis induction. PLoS Pathog. 2010 Feb 19;6(2):e1000774.  Link

Useful review

Rikihisa Y, Lin M, Niu H. Type IV secretion in the obligatory intracellular bacterium Anaplasma phagocytophilum. Cell Microbiol. 2010 Sep 1;12(9):1213-21.  Link

 

Feb. 17  Tiller

Assigned article

MacIntyre DL, Miyata ST, Kitaoka M, Pukatzki S.  The Vibrio cholerae type VI secretion system displays antimicrobial properties. Proc Natl Acad Sci U S A. 2010 Nov 9;107(45):19520-4. Epub 2010 Oct 25.  Link  Supplement

Useful review

Jani AJ, Cotter PA.  Type VI secretion: not just for pathogenesis anymore.  Cell Host Microbe. 2010 Jul 22;8(1):2-6.  Link

 

Tuesday, Feb. 22. 

Specific Aims Presentations

 

Thursday, Feb. 24. 

Specific Aims Presentations

 

If you have trouble with obtaining the .pdf file via the link, please contact Dr. Norris at Steven.J.Norris@uth.tmc.edu.)