Molecular Basis of Microbial Pathogenesis - 2011

MicPath Articles - April

Note: It may be necessary to log in to the HAM-TMC Library website to acquire some of the articles.

 

Surface Structures and Virulence, ctd.

(Dr. Ton-That)

Tuesday, April 5.

Assigned Article:

Dual role for pilus in adherence to epithelial cells and biofilm formation in Streptococcus agalactiae. PLoS Pathog. 2009 May;5(5):e1000422.  Link

 

Metagenomics and Pathogen Discovery

(Dr. Koehler)

All class discussions will relate the Paper to one or more issues addressed in the following Review.

Review:

Lipkin WI. Microbe hunting.  Microbiol. Mol. Biol. Rev. 2010 Sep;74(3):363-377.  Link

 

Thursday, April 7.        

Assigned Article:

Finkbeiner SR, Holtz LR, Jiang Y, Rajendran P, Franz CJ, Zhao G, Kang G, Wang D.  Human stool contains a previously unrecognized diversity of novel astroviruses.  Virol J. 2009 Oct 8;6:161.  Link

 

Tuesday, April 12.        

Microbiology and Molecular Genetics Retreat  (Please Attend)

 

Thursday, April 14.        

Assigned Article:

Greninger AL, Chen EC, Sittler T, Scheinerman A, Roubinian N, Yu G, Kim E, Pillai DR, Guyard C, Mazzulli T, Isa P, Arias CF, Hackett J, Schochetman G, Miller S, Tang P, Chiu CY.  A metagenomic analysis of pandemic influenza A (2009 H1N1) infection in patients from North America.  PLoS One. 2010 Oct 18;5(10):e13381.  Link

 

Tuesday, April 19.        

Assigned Article:

Rubins KH, Hensley LE, Relman DA, Brown PO.  Stunned silence: gene expression programs in human cells infected with monkeypox or vaccinia virus.  PLoS One. 2011 Jan 18;6(1):e15615.  Link

 

Host Interactions and Immune Evasion

(Dr. Norris)

Thursday, April 21.        

Assigned Article:

Moriarty, T. J., M. U. Norman, P. Colarusso, T. Bankhead, P. Kubes, and G. Chaconas. 2008. Real-time high resolution 3D imaging of the Lyme disease spirochete adhering to and escaping from the vasculature of a living host. PLoS Pathog. 4:e1000090.  Link 

(See videos under Supporting Information.  Videos require IrfanView, which can be downloaded from http://www.irfanview.com/main_download_engl.htm .)

Related Article:

Norman, M. U. et al.  2009.  Molecular Mechanisms Involved in Vascular Interactions
of the Lyme Disease Pathogen in a Living Host.  PLoS Pathogens 4:e1000169.  Link

 

Tuesday, April 26.        

Assigned Article:

Lee, W.-Y., T. J. Moriarty, C. H. Y. Wong, H. Zhou, R. M. Strieter, N. van Rooijen, G. Chaconas, and P. Kubes. An intravascular immune response to Borrelia burgdorferi involves Kupffer cells and iNKT cells. Nat. Immunol. 11:295-302. Article, Supplemental Video Legends , SuppVideo1, SuppVideo2, SuppVideo3, SuppVideo4, SuppVideo5, SuppVideo6, SuppVideo7, SuppVideo8, SuppVideo9, SuppVideo10, Supplemental Text, Figures
Videos require Quicktime for viewing.  I recommend viewing at least videos 2, 5, 6, and 9.

 

Thursday, April 28.        

Assigned Article:

Cahoon, L. A. and H. S. Seifert. 2009. An alternative DNA structure is necessary for pilin antigenic variation in Neisseria gonorrhoeae.  Science 325:764-767.  Link

Background Article:

A. K. Criss, K. A. Kline, H. S. Seifert. (2005) The frequency and rate of pilin antigenic variation in
Neisseria gonorrhoeae.  Mol. Microbiol. 58:510-519.  Link

 

If you have trouble with obtaining the .pdf file via the link, please contact Dr. Norris at Steven.J.Norris@uth.tmc.edu.)