Molecular Basis of Microbial Pathogenesis - 2011
MicPath Articles - April
Note: It may be necessary to log in to the HAM-TMC Library website to acquire some of the articles.
Surface Structures and Virulence, ctd.
Tuesday, April 5.
Dual role for pilus in adherence to epithelial cells and biofilm formation in Streptococcus agalactiae. PLoS Pathog. 2009 May;5(5):e1000422. Link
Metagenomics and Pathogen Discovery
All class discussions will relate the Paper to one or more issues addressed in the following Review.
Lipkin WI. Microbe hunting. Microbiol. Mol. Biol. Rev. 2010 Sep;74(3):363-377. Link
Thursday, April 7.
Finkbeiner SR, Holtz LR, Jiang Y, Rajendran P, Franz CJ, Zhao G, Kang G, Wang D. Human stool contains a previously unrecognized diversity of novel astroviruses. Virol J. 2009 Oct 8;6:161. Link
Tuesday, April 12.
Microbiology and Molecular Genetics Retreat (Please Attend)
Thursday, April 14.
Greninger AL, Chen EC, Sittler T, Scheinerman A, Roubinian N, Yu G, Kim E, Pillai DR, Guyard C, Mazzulli T, Isa P, Arias CF, Hackett J, Schochetman G, Miller S, Tang P, Chiu CY. A metagenomic analysis of pandemic influenza A (2009 H1N1) infection in patients from North America. PLoS One. 2010 Oct 18;5(10):e13381. Link
Tuesday, April 19.
Rubins KH, Hensley LE, Relman DA, Brown PO. Stunned silence: gene expression programs in human cells infected with monkeypox or vaccinia virus. PLoS One. 2011 Jan 18;6(1):e15615. Link
Host Interactions and Immune Evasion
Thursday, April 21.
Moriarty, T. J., M. U. Norman, P. Colarusso, T. Bankhead, P. Kubes, and G. Chaconas. 2008. Real-time high resolution 3D imaging of the Lyme disease spirochete adhering to and escaping from the vasculature of a living host. PLoS Pathog. 4:e1000090. Link
(See videos under Supporting Information. Videos require IrfanView, which can be downloaded from
Norman, M. U. et al. 2009. Molecular Mechanisms Involved in Vascular Interactions
of the Lyme Disease Pathogen in a Living Host. PLoS Pathogens 4:e1000169. Link
Tuesday, April 26.
Lee, W.-Y., T. J. Moriarty, C. H. Y. Wong, H. Zhou, R. M. Strieter, N. van Rooijen, G. Chaconas, and P. Kubes. An intravascular immune response to Borrelia burgdorferi involves Kupffer cells and iNKT cells. Nat. Immunol. 11:295-302. Article, Supplemental Video Legends , SuppVideo1, SuppVideo2, SuppVideo3, SuppVideo4, SuppVideo5, SuppVideo6, SuppVideo7, SuppVideo8, SuppVideo9, SuppVideo10, Supplemental Text, Figures
Videos require Quicktime for viewing. I recommend viewing at least videos 2, 5, 6, and 9.
Thursday, April 28.
Cahoon, L. A. and H. S. Seifert. 2009. An alternative DNA structure is necessary for pilin antigenic variation in Neisseria gonorrhoeae. Science 325:764-767. Link
A. K. Criss, K. A. Kline, H. S. Seifert. (2005) The frequency and rate of pilin antigenic variation in
Neisseria gonorrhoeae. Mol. Microbiol. 58:510-519. Link
If you have trouble with obtaining the .pdf file via the link, please contact Dr. Norris at Steven.J.Norris@uth.tmc.edu.)