Department of Pathology & Laboratory Medicine

Publications

    • Hu B, Margolin W, Molineux IJ, Liu J: The Bacteriophage T7 Virion Undergoes Extensive Structural Remodeling during infection, Science, 2013 Jan 10. [Epub ahead of print]. PMID:23306440
    • Liu J, Hu B, Morado DR, Jani S, Manson MD, Margolin W: Molecular architecture of chemoreceptor arrays revealed by cryoelectron tomography of Escherichia coli minicells. Proc Natl Acad Sci USA 2012 May 3. 109(23): E1481-8. PMCID: PMC3384206
    • Raddi G, Morado DR, Yan J, Haake DA, Yang XF, Liu J: Three-Dimensional Structures of Pathogenic and Saprophytic Leptospira Revealed by Cryo-Electron Tomography. J Bacteriol 2012 Mar;194(6):1299-306. PMCID: PMC3294836
    • Zhang K, Liu J, Tu Y, Xu H, Charon NW, Li C: Two CheW coupling proteins are essential in a chemosensory pathway of Borrelia burgdorferi. Mol Microbiol. 2012 Aug;85(4):782-94. PMCID: PMC3418435
    • Wu S, Liu J, Reedy MC, Perz-Edwards RJ, Tregear RT, Winkler H, Franzini-Armstrong C, Sasaki H, Lucaveche C, Goldman YE, Reedy MK, Taylor KA: Structural Changes in Isometrically Contracting Insect Flight Muscle Trapped following a Mechanical Perturbation. PLoS One. 2012;7(6):e39422. Epub 2012 Jun 25. PMID: 22761792
    • Fu X, Walter MH, Paredes A, Morais MC, Liu J: The mechanism of DNA ejection in the Bacillus anthracis spore-binding phage 8a revealed by cryo-electron tomography. Virology 2011 Dec 20;421(2):141-8. PMID: 22018785
    • Luther PK, Winkler H, Taylor K, Zoghbi ME, Craig R, Padrón R, Squire JM, Liu J: Direct visualization of myosin-binding protein C bridging myosin and actin filaments in intact muscle. Proc Natl Acad Sci USA 2011 108(28):11423-8. PMCID: PMC3136262
    • Hu G, Liu J, Taylor KA, Roux KH: Structural comparison of HIV-1 envelope spikes with and without the V1/V2 loop. J Virol. 2011 Mar;85(6):2741-50. PMCID: PMC3067966
    • Liu J, Chen CY, Shiomi D, Niki H, Margolin W: Visualization of bacteriophage P1 infection by cryo-electron tomography of tiny Escherichia coli. Virology 2011 Sep 1;417(2):304-11. PMCID: PMC3163801
    • Motaleb MA, Pitzer JE, Sultan SZ, Liu J: A novel gene inactivation system reveals an altered periplasmic flagellar orientation in a Borrelia burgdorferi fliL mutant. J Bacteriol. 2011 193(13):3324-31. PMCID: PMC3133274
    • Sze CW, Morado DR, Liu J, Charon NW, Xu H, Li C: Carbon storage regulator A (CsrA(Bb)) is a repressor of Borrelia burgdorferi flagellin protein FlaB. Mol Microbiol 2011 Nov;82(4):851-64. PMCID: PMC3212630
    • Liu J, Wright ER, Winkler H: 3D visualization of HIV virions by cryoelectron tomography. Methods Enzymol. 2010, 483:267-90. PMCID: PMC3056484
    • Wu S, Liu J, Reedy MC, Tregear RT, Winkler H, Franzini-Armstrong C, Sasaki H, Lucaveche C, Goldman YE, Reedy MK, Taylor KA: Electron tomography of cryofixed, isometrically contracting insect flight muscle reveals novel actin-myosin interactions. PLoS One. 2010, 5(9). PMCID: PMC2936580
    • Liu J, Howell JK, Bradley SD, Zheng Y, Zhou ZH, Norris SJ: Cellular architecture of Treponema pallidum: novel flagellum, periplasmic cone, and cell envelope as revealed by cryo electron tomography. J Mol Biol. 2010, 403(4):546-61. PMCID: PMC2957517

    References:

    • Liu J, Lin T, Botkin DJ, McCrum E, Winkler H, Norris SJ: Intact Flagellar Motor of Borrelia burgdorferi Revealed by Cryo-Electron Tomography: Evidence for Stator Ring Curvature and Rotor/C Ring Assembly Flexion, J Bacteriol 2009 191(16):5026-36.
    • Wu S, Liu J, Reedy MC, Winkler H, Reedy MK, Taylor KA: Methods for Identifying and Averaging Variable Molecular Conformations in Tomograms of Actively Contracting Insect Flight Muscle. J Struct Biol 2009 Aug 19. [Epub ahead of print].
    • Sanabria H, Swulius MT, Kolodziej SJ, Liu J, Waxham NM: CaMKII Regulates Actin Assembly and Structure, J Biol Chem 2009 284(15):9770-80.
    • Winkler H, Zhu P, Liu J, Ye F, Roux KH, Taylor KA: Tomographic subvolume alignment and subvolume classification applied to myosin V and SIV envelope spikes. J Struct Biol 2009 165(2):64-77.
    • Liu J, Bartesaghi A, Borgnia M, Sapiro G, Subramaniam S: Molecular architecture of native HIV-1 gp120 trimers. Nature 2008 455:109-113.
    • Hampton CM, Liu J, Taylor DW, DeRosier DJ, Taylor KA: The 3D Structure of Villin as a Unique F-Actin Crosslinker. Structure. 2008 16(12):1882-91.
    • Ye F, Liu J, Winkler H, Taylor KA: Integrin IIba3 in a membrane environment remains the same height after Mn2+ Activation when observed by cryo-electron tomography. J Mol Biol 2008 378:976-86.
    • Miao L, Vanderlinde O, Liu J, Grant R, Wouterse A, Philipse A, Stewart M, Roberts TM: Filament packing constraints generate protrusive force in amoeboid cell motility. PNAS 2008 105:5390-5.
    • Bartesaghi A, Sprechmann P, Liu J, Randall G, Sapiro G, Subramaniam S: Classification and 3D averaging with missing wedge-correction in biological electron tomography. J Struct Biol 2008162:436-50
    • Dai W, Jia Q, Bortz E, Shah S, Liu J, Atanasov I, Li X, Taylor KA, Sun R, Zhou ZH: Unique structures in a tumor herpesvirus revealed by cryo-electron tomography and microscopy. J Struct Biol 2008 161:428-438.
    • Liu J, McBride MJ, Subramaniam S: Cell-surface filaments of the gliding bacterium Flavobacterium johnsoniae revealed by cryo-electron tomography. J Bacteriol 2007 189: 7503-7506.
    • Subramaniam S, Bartesaghi A, Liu J, Bennett AE, and Sougrat R: Electron tomography of viruses. Current Opinion in Structural Biology 2007 5:596-602.
    • Bennett AE, Liu J, Van Ryk D, Bliss D, Arthos J, Henderson R M, Subramaniam S: Cryo electron tomographic analysis of an HIV neutralizing protein and its complex with native viral gp120. J Biol Chem 2007, 282(38): 27754-27759.
    • Liu J, Taylor DW, Krementsova EB, Trybus KM, Taylor KA: Three-dimensional structure of the myosin V inhibited state by cryoelectron tomography. Nature 2006, 442:208-211.
    • Zhu P, Liu J, Bess J, Jr., Chertova E, Lifson JD, Grise H, Ofek GA, Taylor KA, Roux KH: Distribution and three-dimensional structure of AIDS virus envelope spikes. Nature 2006, 441:847-852
    • Liu J, Wu S, Reedy MC, Winkler H, Lucaveche C, Cheng Y, Reedy MK, Taylor KA: Electron tomography of swollen rigor fibers of insect flight muscle reveals a short and variably angled S2 domain. J Mol Biol 2006, 362:844-860
    • Liu J, Reedy MC, Goldman YE, Franzini-Armstrong C, Sasaki H, Tregear RT, Lucaveche C, Winkler H, Baumann BA, Squire JM, Irving TC, Reedy MK, Taylor KA: Electron tomography of fast frozen, stretched rigor fibers reveals elastic distortions in the myosin crossbridges. J Struct Biol 2004, 147:268-282
    • Liu J, Taylor DW, Taylor KA: A 3-D reconstruction of smooth muscle alpha-actinin by CryoEm reveals two different conformations at the actin-binding region. J Mol Biol 2004, 338:115-125
    • Tama F, Feig M, Liu J, Brooks CL, 3rd, Taylor KA: The requirement for mechanical coupling between head and S2 domains in smooth muscle myosin ATPase regulation and its implications for dimeric motor function. J Mol Biol 2005, 345:837-854
    • Liu J, Wendt T, Taylor D, Taylor K: Refined model of the 10S conformation of smooth muscle myosin by cryo-electron microscopy 3D image reconstruction. J Mol Biol 2003, 329:963-972
      21. Zhu P, Chertova E, Bess J, Jr., Lifson JD, Arthur LO, Liu J, Taylor KA, Roux KH: Electron tomography analysis of envelope glycoprotein trimers on HIV and simian immunodeficiency virus virions. PNAS 2003, 100:15812-15817
    • Book chapter:
      Goldstein SF, Li C, Liu J, Miller M, Motaleb M, Norris SJ, Silversmith RE, Wolgemuth CW, Charon NW: The Chic Motility and Chemotaxis of Borrelia burgdorferi. In: Borrelia: Molecular and Cellular Biology, Edited by D. Scott Samuels, in press.