HYPOFIBRINOGENEMIA

• Biochemical aspects:
  Please refer to the section on "Afibrinogenemia" for further information on biochemical aspects of fibrinogen.
• Pathological Basis:
  • Mode of inheritance: autosomal dominant or autosomal recessive.
  • The fibrinogen level in patients with this disorder is usually less than 100 mg/dl. They may have a mild tendency to bleed.
• Treatment:
  • Cryoprecipitate.
  • Avoidance of aspirin-containing compounds.
  • Dosage: the amount of fibrinogen (in mg) required can be calculated from:
    • 40*BW*(desired fibrinogen level-actual fibrinogen level)/100
    • Where BW is body weight in kg