PLATELET CONCENTRATE
Andy Nguyen,M.D./ UT-Medical School at Houston, Pathology/
Last Revision on: 8/15/99
Random-donor platelet:
- Composition:
platelets (>5.5*1010 /unit), WBC's, plasma,
RBC's.
- Supply format:
one unit (bag) contains 50 ml. One dose consists
of 6 units. Shelf life is 3-5 days.
- Indication:
thrombocytopenia or thrombocytopathy.
- Dosage:
For a 70 kg adult, one unit of random-donor platelets will
increase the platelet count by 3,000-10,000/ul. For children, one unit of random-donor platelet will
increase the platelet count by 3,000/ul per 1 kg of body
weight.
Single-donor platelet:
- Composition:
platelets (>3*1011 /units), WBC's,plasma,
RBC's.
- Supply format:
one bag contains 300 ml. Shelf life is 24 hours.
- Indication:
thrombocytopenia in patients with HLA platelet
antibodies. Product is often HLA-matched.
- Dosage:
For a 70 kg body-weight adult, one unit
of single-donor platelet will increase the platelet count
by 30,000-60,000/ul.
In children, one unit of single-donor platelet will increase
the platelet count by 18,000/ul per 1kg of body weight.
Note:
- Repeated platelet transfusion may lead to alloimmunization
to HLA antigen and development of a refractory state
requiring HLA-matched platelets.
- Platelet transfusion is contraindicated in patients with
ITP or TTP.