SPONTANEOUS INHIBITOR OF FACTOR VIII

• Pathological Basis:
  • The etiologic basis of antibodies to factor VIII:C in persons without hemophelia is unknown. They are not related to previous exposure to blood products. Typically, such patients do not demonstrate an anamnestic response on exposure to factor VIII.
  • Spontaneous development of factor VIII:C inhibitor arise in a number of different clinical situations, including: collagen vascular diseases, pregnancy, drugs (penicilin, sulfa, gold), and occasionally are found in patients with no obvious underlying disease.
• Treatment:
  • Factor VIII concentrates for active bleeding.
  • Immunosuppressive therapy (azathioprine or cyclophosphamide) may be effective.