Adaptive Immune Responses: Activation of B and T Cells by Antigen

 

PowerPoint Lecture Slides: Adaptive Immune Response I & II Lecture 01/23/14

 

Immunobiology Ultranet Biology Pages: Hypersensitive Reactions

Molecular Immunology

Functional Classes of Cytokines [Eur J Immunol. 2007. 37:S34-45]

Immunology Glossary

Ultranet Biology Pages (see Immunology)

 

ENCYCLOPEDIA OF LIFE SCIENCES 2009 DTH article Lymphocyte Review Article

Summary Table

(from http://users.rcn.com/jkimball.ma.ultranet/BiologyPages/T/Th1_Th2.html#summary )

Type

Cytokine Stimulus

Master
Transcription Factor

Effector Cytokine(s)

Main Target Cells

Effector Functions

Pathological Effects

Th1

IL-12

T-bet

IFN-γ & IL-2

Macrophages, dendritic cells

Intracellular pathogens

Autoimmunity;
cell-mediated allergies

Th2

IL-4

GATA-3

IL-4, IL-5 & IL-13

Eosinophils, basophils, B cells

Extracellular pathogens

Asthma and IgE-mediated allergies

Tfh

IL-6 & IL-21

Bcl6

IL-21

B cells

Class Switch Recombination and Affinity Maturation of antibodies

Autoimmune diseases?

Th17

TGF-β plus IL-6
Inhibited by retinoic acid

RORγt

IL-17 & IL-22

Neutrophils

Extracellular bacteria;
mediates inflammation

Autoimmune diseases

Treg

TGF-β minus IL-6
Stimulated by retinoic acid and IL-2

Foxp3

IL-10 & TGF-β

all the other types of T cells

Immunosuppression; anti-inflammatory

None?

 

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