HIV-1 Progress
A resource for donors, collaborators and potential study subjects
Our research on HIV therapy and vaccination has recently received considerable community support. We are committed to bring our studies to clinical translation. Following are links to recent technical presentations that provide the foundation for further therapeutic and preventative vaccination developments.
We are thankful for all of the support from the HIV community, particularly patients who have volunteered for clinical trials. We are working hard to obtain funds and set up the infrastructure to rapidly implement the clinical trials.
Sincerely,
Sudhir Paul and the Chemical Immunology Research Center
Synposis of Basic Science Publications Supporting Abzyme Therapy for HIV
Publications
- Nishiyama, Y., Planque, S., Mitsuda, Y., Nitti, G., Taguchi, H., Jin, L., Symersky, J., Boivin, S., Sienczyk, M., Salas, M., Hanson, C.V., and Paul, S. Towards effective HIV vaccination: Induction of binary epitope reactive antibodies with broad HIV neutralizing activity. J Biol Chem. In press. DOI: 10.1074/jbc.M109.032185 Article
- Paul, S., Planque, S.A., Nishiyama, Y., and Hanson, C.V. A covalent HIV vaccine: Is there hope for the future? Future Virology (Editorial) 4:7-10, 2009. Article
- Planque, S., Salas, M., Escobar, M.E., Morris, M.-K., Jena, B., Mitsuda, Y., Sienczyk, M., Nishiyama, Y., Kumar, A., Gao, F., Montefiori, D.C., Hanson, C.V., and Paul, S. Survivors of HIV infection produce potent, broadly neutralizing IgAs directed to the superantigenic region of the gp120 CD4 binding site. XVII International AIDS Conference (AIDS 2008), 3-8 August, 2008, México City, México. Abstract Number THAA0305. Abstract Slides
- Planque, S., Sienczyk, M., Nishiyama, Y., Salas, M., Sapparapu, G., Mitsuda, Y., Taguchi, H., Boivin, S., Nitti, G., Montefiori, D., Hanson, C.V., and Paul, S. Prospective clinical utility and evolutionary implication of broadly neutralizing antibody fragments to HIV gp120 superantigenic epitope. XVII International AIDS Conference (AIDS 2008), 3-8 August, 2008, México City, México. Abstract Number LBPE1134. Abstract Full poster presentation
- Planque, S., Nishiyama, Y., Taguchi, H., Salas, M., Hanson, C., and Paul, S. Catalytic antibodies to HIV: Physiological role and potential clinical utility. Autoimmun Rev. (Invited Review) 7:473-479, 2008. Abstract
- Planque, S., Mitsuda, Y., Taguchi, H., Salas, M., Morris, M.-K., Nishiyama, Y., Kyle, R., Okhuysen, P., Escobar, M., Hunter, R., Sheppard, H.W., Hanson, C., and Paul, S. Characterization of gp120 hydrolysis by IgA antibodies from humans without HIV infection. AIDS Res Hum Retroviruses. 23:1541-1553, 2007. Abstract
- Nishiyama, Y., Karle, S., Planque, S., Taguchi, H., and Paul, S. Antibodies to the superantigenic Site of HIV-1 gp120: Hydrolytic and binding activities of the light chain subunit. Mol Immunol. 44:2707-2718, 2007. Abstract
- Nishiyama, Y., Mitsuda, Y., Taguchi, H., Planque, S., Salas, M., Hanson, C.V., and Paul, S. Towards covalent vaccination: Improved polyclonal HIV neutralizing antibody response induced by an electrophilic gp120 V3 peptide analog. J Biol Chem. 282:31250-31256, 2007. Abstract
- Nishiyama, Y., Karle, S., Mitsuda, Y., Taguchi, H., Planque, S., Salas, M., Hanson, C., and Paul, S. Towards irreversible HIV inactivation: stable gp120 binding by nucleophilic antibodies. J Mol Recognit. 19:423-431, 2006. Abstract
- Paul, S., Karle, S., Planque, S., Taguchi, H., Salas, M., Nishiyama, Y., Handy, B., Hunter, R., Edmundson, A., and Hanson, C. Naturally occurring proteolytic antibodies: Selective IgM-catalyzed hydrolysis of HIV gp120. J Biol Chem. 279:39611-39619, 2004. Abstract
- Karle, S., Planque, S., Nishiyama, Y., Taguchi, H., Zhou, Y.-X., Salas, M., Lake, D., Thiagarajan, P., Arnett, F., Hanson, C.V., and Paul, S. Cross-clade HIV-1 neutralization by an antibody fragment from a lupus phage display library. AIDS. 18:329–331, 2004. Abstract
- Paul, S., Planque, S., Zhou, Y.-X., Taguchi, H., Bhatia, G., Karle, S., Hanson, C., and Nishiyama, Y. Specific HIV gp120 cleaving antibodies induced by covalently reactive analog of gp120. J Biol Chem. 278:20429-20435, 2003. Abstract
- Nishiyama, Y., Planque, S., Mitsuda, Y., Taguchi, H., Jin, L., Boivin, S., Salas, M., Hanson, C., and Paul, S. A binary neutralizing determinant of gp120 defined by nucleophilic monoclonal antibodies. 4th IAS Conference on HIV Pathogenesis, Treatment and Prevention (IAS 2007).July 22-25, 2007; Sydney, Australia. Abstract# TUPEA042. Poster presentation
News
The following are links to news outlets with reports on our research.
