Heart Failure (continued)
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Damaged myocardium
Roger Bick, Brian Poindexter, O.H. Frazier (THI)
Myofibrils in disarray exhibiting a great deal of discontinuity and fraying. Sample from a heart failure patient prior to insertion of an LVAD. Reference:
Bick RJ et al, J. Heart and Lung Transpl; 24:454-461, 2005.
Post-LVAD myocardium
Roger Bick, Pippa Schnee, Brian Poindexter, O.H. Frazier, Cardiac myofibrils showing compact form, visible intercalated discs and copious beta-adrenoreceptors, following unloading with LVAD. Reference: Bick RJ et al, J. Cardiac Surg; 20:1-5, 2005.
β receptors post-LVAD
Roger Bick, Alina Grigore, O.H. Frazier, L. Max Buja, Brian Poindexter, Up-regulation of beta adrenoreceptors (yellow) in straight, continuous, compact myofibrils following ventricular unloading with LVAD. Reference: Bick RJ et al, J. Cardiac Surg; 20:1-5, 2005.
Microvessel in myocardium
Brian Poindexter, Roger Bick, Localization of small blood vessels (blue/lilac) coursing between contractile proteins (green) before ventricular unloading. Red shows position of alpha-adrenergic receptors. Reference: Grigore A et al, J. Heart and Lung Transplantation; 24(5):609-613, 2005.
Neonatal myocyte
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Nucleus receptors
3D model constructed from stacked image acquisitions to show the nucleus blue, cardiac myosin (green) and beta-adrenergic receptors (red) prior to ventricular unloading. Reference:
Bick RJ et al, J. Cardiac Surg; 20:1-5, 2005.
Myocyte
Brian Poindexter, Barry Van Winkle, Roger Bick
Funky, Catherine wheel neonatal myocyte, showing nucleus, adrenoreceptors, and cardiac myosin. Reference:
Bick RJ et al, Cell Adhes. Comm; 6:301-310, 1998.
Smooth muscle actin
Barry Van Winkle, Roger Bick and Brian Poindexter, Smooth muscle actin (red) seen in this cultured, dedifferentiating adult cardiomyocyte. Reference: Bick RJ et al, Cell Adhes. Comm; 6:301-310, 1998.
