Getting To and From The Medical Center

Drivers can select the most efficient route into the Texas Medical Center from starting points throughout Houston.

Intercontinental Airport/I-59 traveling south

• Take Will Clayton Blvd. East to Highway 59.
• Turn right on Highway 59 south and follow it to Highway 288.
• Exit onto Highway 288 and follow it south to the N. MacGregor Way exit.
• Turn right (west) onto N. MacGregor Way and follow directional signage to destination.

Hardy Toll Road traveling south

• Take Hardy Toll Road south to Loop 610.
• Follow 610 East and exit at highway 59 South.
• Exit onto Highway 288 and follow it south to the N. MacGregor Way exit.
• Turn right (west) onto N. MacGregor Way and follow directional signage to destination.

I-45 traveling south

• Exit onto Highway 59 South
• From Highway 59, exit onto Highway 288 and follow it south to the N. MacGregor Way exit.
• Turn right (west) onto N. MacGregor Way and follow directional signage to destination.

Highway 290 traveling east

• Merge onto Loop 610 East
• Take Loop 610 south to I-10 East.
• Exit Highway 59 South.
• Travel 59 South to Highway 288.
• Follow Highway 288 South to the N. MacGregor Way exit.
• Turn right (west) onto N. MacGregor Way and follow directional signage to destination.

I-59 traveling north

• Travel Highway 59 North to highway 288 South.
• Take Highway 288 South to N. MacGregor Way.
• After exiting, turn right (west) onto N. MacGregor Way and follow directional signage to destination.

Hobby Airport/I-45 traveling North

• Take Broadway east to I-45.
• Turn left (north) on I-45 and follow it to Loop 610.
• Head west on Loop 610.
• From Loop 610, take the Fannin St. exit.
• Turn right (north) on Fannin St. and follow directional signage to destination.

Highway 288 traveling north

• Take the N. MacGregor Way exit.
• Turn left (west) onto N. MacGregor Way and follow directional signage to destination.

I-10 traveling west

• Exit Highway 59 heading south.
• From Highway 59, exit onto Highway 288 and follow it south to the N. MacGregor Way exit.
• Turn right (west) onto N. MacGregor Way and follow directional signage to destination.

I-10 traveling east

• Exit I-45 heading south.
• From I-45, exit onto Highway 59 heading south.
• From Highway 59, exit onto Highway 288 heading south and follow it to the N. MacGregor Way exit.
• Turn right (west) onto N. MacGregor Way and follow directional signage to destination.