Hematology Faculty
Harinder S. Juneja, M.D.
Professor & Division Director
Biographical Sketch
6431 Fannin, MSB 5.016
Houston, Texas 77030
Tel: 713-500-6773
Fax: 713-500-6812
Email: Harinder.S.Juneja@uth.tmc.edu
Miguel Escobar, M.D.
Associate Professor
Biographical Sketch
6655 Travis, HMC 400
Houston, Texas 77030-1312
Tel: 713-500-8360
Fax: 713-500-8364
Email: Miguel.Escobar@uth.tmc.edu
Research Interests
My interests are in clinical and translational research involving bleeding and hemostasis in patients with hemophilia and other congenital and acquired bleeding disorders.
Modupe Idowu, M.D.
Assistant Professor
Biographical Sketch
6431 Fannin, MSB 5.287
Houston, Texas 77030
Tel: 713-500-6764
Fax: 713-500-6812
Email: Modupe.Idowu@uth.tmc.edu
Research Interests
My interests are in treating patients with sickle cell anemia, myeloproliferative neoplasm, thrombotic disorders, and hematologic malignancy including lymphoproliferative disorders, plasma cell dyscracias, and leukemias.
I have special interests in clinical and translational research involving sickle cell anemia and thrombotic disorders. I have previously done research work on the use of hydroxyurea in sickle cell anemia. I am currently working, in collaboration with Dr. Juneja (Hematology division) and Dr. Yang Xia of the Department of Biochemistry and Molecular Biology, on the role of adenosine in pathophysiology of sickle cell anemia. Our data shows that excess adenosine can increase polymerization of hemoglobin S.
I will also be evaluating the effect of sickle cell anemia on patients’ academic achievement and job performance. This project will be in collaboration with The University of Texas School of Public Health.
Richard Kulmacz, Ph.D.
Professor
Biographical Sketch
6431 Fannin, MSB 5.288
Houston, Texas 77030
Tel: 713-500-6772
Fax: 713-500-6810
Email: Richard.J.Kulmacz@uth.tmc.edu
Research Interests
Eicosanoids are very potent cellular signalling molecules derived from polyunsaturated fatty acids. Their name comes from the prototypical polyunsaturated fatty acid, eicosatetraenoic acid (arachidonic acid), and the class includes prostaglandins, leukotrienes, hydroxy fatty acids, and epoxy fatty acids. Eicosanoids have been implicated in a wide variety of pathophysiological processes, including carcinogenesis, hemostasis, inflammation, renal function, reproduction, and sleep/wake cycles. My general interest is in understanding at the molecular level how eicosanoid biosynthesis is accomplished and how it is regulated.
A major control point in eicosanoid biosynthesis is the initial oxygenation of fatty acid to form a lipid hydroperoxide, catalyzed by one of several fatty acid oxygenases. My lab’s focus at present is on two major areas: the roles of substrate structure, redox environment and human enzyme polymorphisms on regulation of prostaglandin synthesis, and the relationship between structure and function among human cytochrome b561 family members.
Ah-Lim Tsai, Ph.D.
Professor
Biographical Sketch
6431 Fannin, MSB 5.290
Houston, Texas 77030
Tel: 713-500-6771
Fax: 713-500-6810
Email: Ah-Lim.Tsai@uth.tmc.edu
Ongoing Research Topics
The central theme of my research is to understand the reaction mechanism of several crucial heme-containing proteins that are involved in regulatory functions and the pathological processes of the cardiovascular system. Prostaglandins and nitric oxide (NO) are two important mediators in hemostasis. For example, prostacyclin and NO released by endothelial cells are strong vasodilators and potent inhibitors of platelet aggregation, whereas thromboxane and prostaglandin G2/H2 released by platelets are potent agonists of platelet aggregation and vasoconstriction. All these compounds are short-lived autocoids. A balanced production and timely release of these potent hormones are crucial in maintaining a normal vascular tone and an imbalanced synthesis of these mediators usually leads to pathological conditions.
Expertise
Metelloenzymes, esp. Hemeproteins Electron transfer and redox reactions Enzyme kinetics, mainly transient kinetics (stopped-flow, rapid-freezing and rapid quench) Computer modeling and simulation Bioenergetics Mitochondria (structure and function) Membrane-bound proteins Prostaglandins, receptors, binding proteins and signal transduction Prostaglandin H synthase and nonsteroidal anti-inflammatory agents Nitric oxide and nitric oxide synthase Spectroscopic methods (UV-VIS, fluorescence, EPR and MCD).
Lee-Ho Wang, Ph.D.
Associate Professor
Biographical Sketch
6431 Fannin, MSB 5.216
Houston, Texas 77030
Tel: 713-500-6794
Fax: 713-500-6810
Email: Lee-Ho.Wang@uth.tmc.edu
Research Interests
My interests are in the investigation of structure-function relationships of thromboxane synthase and prostacyclin synthase.
Gang Wu, Ph.D.
Instructor
Biographical Sketch
6431 Fannin, MSB 3.324
Houston, Texas 77030
Tel: 713-500-6802
Fax: 713-500-6812
Email: Gang.Wu@uth.tmc.edu
Research Interests
My research interests are in the catalytical mechanism of prostaglandin H synthase.
Kenneth K. Wu, M.D., Ph.D.
Professor Emeritus
Biographical Sketch
Current Position:
President of National Health Research Institutes
Taiwan 35, Keyan Road, Zhunan Township, Miaoli County
350 Taiwan
Tel: 886-37-246-166, Ext. 31000
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Division of Renal Diseases and Hypertension
The Division of Renal Diseases and Hypertension strives to provide state-of-the-art patient care, innovative teaching, and cutting edge research.
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