Department of Internal Medicine
Department of Internal Medicine

Rheumatology Research

Major areas of investigative interest focus on the molecular biology and genetics underlying multisystem inflammatory rheumatic and autoimmune diseases, especially systemic lupus erythematosus, scleroderma, Sjogren's syndrome, polymyositis, rheumatoid arthritis and the spondyloarthropathies. State-of-the-art molecular genetic technology and analyses are being used to map susceptibility genes to these diseases and to identify biomarkers of disease activity and prognosis as well as to identify molecular pathways which can be targeted therapeutically.

Examples of our research include (click on study icon see bibliography):

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The Austro-Anglo-American Spondylitis Consortium
John D. Reveille, M.D., PI

UTCORT

Centers of Research Translation in Scleroderma Maureen D. Mayes, M.D., MPH, PI

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SCOT
Scleroderma Cyclophosphamide or Transplant
(2005-2012)
Maureen D. Mayes, M.D., MPH, PI

Ongoing projects at the UT Houston Division of Rheumatology

TITLE
AGENCY
INVESTIGATOR
Candidate Gene Polymorphisms in Scleroderma: Defining Genetic Susceptibility Factors DoD Maureen D. Mayes, MD MPH
Genome-Wide Association Study in Systemic Sclerosis (GWAS) NIH/NIAMS Maureen D. Mayes, MD MPH
The Integrative Studies of Genetic and Environmental Factors in Scleroderma DoD Xiaodong Zhou, MD
UTSA - COGNITION study in Lupus UAB Program Project in the Genetics of SLE NIH John D. Reveille, MD PI - Robin Brey, MD (UTSA)
UAB Program Project in the Genetics of SLE NIH-NIAMS John D. Reveille, MD PI – Robert Kimberly, MD (UAB)
The Architecture of the HLA Region in Systemic Sclerosis and Ankylosing Spondylitis NIH/NIAID Xiaodong Zhou, MD

Rheumatology and Clinical Immunogenetics