Rheumatology and Clinical Immunogenetics

RESEARCH

Major areas of investigative interest focus on the molecular biology and genetics underlying multisystem inflammatory rheumatic and autoimmune diseases, especially systemic lupus erythematosus, scleroderma, Sjogren's syndrome, polymyositis, rheumatoid arthritis and the spondyloarthropathies. State-of-the-art molecular genetic technology and analyses are being used to map susceptibility genes to these diseases and to identify biomarkers of disease activity and prognosis as well as to identify molecular pathways which can be targeted therapeutically.

Examples of our research include (click on study icon see bibliography):

	NIH- Family Studies of Micro Satellite Gene Markers in Patients with Ankylosing Spondylitis John D. Reveille, M.D., PI
	LUMINA NIH R01: Outcome of SLE in Minorities - Nature vs Nurture John D. Reveille, M.D., PI
	LASR 21st Century Lupus, Arthritis, Scleroderma Research into the 21st century Frank C. Arnett, M.D., PI Serological and Immunogenetics Database for Research in Scleroderma and Other Autoimmune Connective Tissue Diseases
	NIAMS SCOR Specialized Center of Research in Scleroderma (1997 - 2006) Frank C. Arnett, M.D., Director
	SCOT Scleroderma Cyclophosphamide or Transplant (2005-2012) Maureen D. Mayes, M.D., MPH, PI

In the fall of 2006, the Division of Rheumatology was awarded several major grants from the National Institutes of Health (NIH), Department of Defense (DoD) and the American College of Rheumatology (ACR).

TITLE	AGENCY	INVESTIGATOR	AMOUNT
The Austro-Anglo-American Spondylitis Consortium	NIH-NIAMS	John D. Reveille, MD	$5 MILLION
Center of Research Translation in Scleroderma	NIH-NIAMS	Frank C. Arnett, MD	$7.5 MILLION
Center for Clinical and Translational Sciences	NIH-NCRR	Frank C. Arnett, MD	$36 MILLION
Candidate Gene Polymorphisms in Scleroderma: Defining Genetic Susceptibility Factors	DoD	Maureen D. Mayes, MD MPH	$625,000
The Integrative Studies of Genetic and Environmental Factors in Scleroderma	DoD	Xiadong Zhou, MD	$928,125
Microarray analysis of peripheral blood cells in systemic sclerosis	ACR REF	Shervin Assassi, MD	$170,000

Internal Medicine General Medical School Health Science Center
Contact Author, PJL Date of Last Edit