A model for nonstop mRNA degradation
Nonstop mRNA degradation is thought to be triggered when a translating ribosome reaches the very 3' end of an mRNA. The ribosome is recognized by the C-terminal domain of Ski7p, possibly because the ribosomal A-site does not contain a codon. Recognition of the ribosome leads to 3' to 5' degradation by a large ribonuclease complex(the exosome).
Location & Contact
6431 Fannin Street,
Houston, Texas 77030
P.O. Box 20708
Houston, Texas 77225
713.500.5500
713.500.5499 fax
Our Affiliations
Our affiliates include the following:
Faculty
- Departmental Faculty
- Sam Kaplan, Ph.D.
- Peter J. Christie, Ph.D.
- Rebecca L. Cox, Ph.D.
- Danielle Garsin, Ph.D.
- Millicent Goldschmidt, Ph.D.
- Heidi Kaplan, Ph.D.
- Theresa M. Koehler, Ph.D.
- Ziyin Li, Ph.D.
- Michael C. Lorenz, Ph.D.
- William Margolin, Ph.D.
- Kevin A. Morano, Ph.D.
- Hung Ton-That, Ph.D.
- Ambro van Hoof, Ph.D.
- Departmental Faculty - Cross Appointees
- William Dowhan, Ph.D.
- Gregory S. May, Ph.D.
- Barbara E. Murray, M.D.
- Steven J. Norris, Ph.D.
- John L. Spudich, Ph.D.
- Stephen K. Tyring, M.D., Ph.D., M.B.A.
- Adjunct Faculty
- Gabriela Bowden, Ph.D.
- Magnus Höök, Ph.D.
- Mark T. Larocco, Ph.D.
- Jun Liu, Ph.D.
- Liliana F. Rodriguez DrPH, MPH, RM(AAM), M(ASCP)
- Research Faculty
- Jesus Eraso, Ph.D.
- Ronald C. MacKenzie, Ph.D.
- Jung Hyeob Roh. Ph.D.
