Gang Zhang, M.D., Ph.D.

Assistant Professor of Neurology

Contact Information:

• Telephone: 713-500-6787
  
• Fax: 713-500-0773
  
• E-mail: Gang.Zhang@uth.tmc.edu

Education and Training:

• M.D., Hebei Medical University, Shijiazhuang, P.R. China
• Ph.D., Neuroscience, Hebei Medical University, Shijiazhuang, P.R. China
• Internship/Residency in Neurology, The Second Hospital of Hebei Medical University, Shijiazhuang, P.R. China
• Postdoctoral Fellowship, Department of Neurology, Johns Hopkins University School of Medicine, Baltimore, Maryland
• Research Associate, Department of Neurology, Johns Hopkins University School of Medicine, Baltimore, Maryland

Publications and Medical/Scientific Participation

• Zhang, G., Li, C., Griffin, J.W., Schnaar, R. L., Sheikh, K. A. Development and characterization of an in vitro antiganglioside antibody mediated neuronal cell lysis assay. (Abstract), Journal of the Peripheral Nervous System. 2003; 8; Supplement 1:77.
• Sheikh, KA., Zhang, G., Schnaar, RL., Griffin, JW. Induction of neuropathy in mice by antibody secreting hybridoma implantation. (Abstract), Journal of the Peripheral Nervous System. 2003; 8; Supplement 1:77 (abstract).
• Zhang, G., Lopez, P. H., Li, C., Griffin, J. W., Mehta, N. R., Schnaar, R. L., and Sheikh, K. A. Anti-ganglioside antibody-mediated neuronal cytotoxicity and its protection by intravenous immunoglobulin: implications for immune neuropathies. Brain. 2004 May;127(Pt 5):1085-1100
• Sheikh, K. A., Zhang, G., Gong, Y., Schnaar, R. L., Griffin, J. W. An anti-ganglioside antibody-secreting hybridoma induces neuropathy in mice. Annals of Neurology. 2004 Aug;56(2):228-239
• Zhang, G., Lopez, P.H., Sheikh K. A. Passive transfer studies in mice over expressing GD1a Ganglioside. Journal of the Peripheral Nervous System. 2005; 10; Supplement 1: 107.
• Lopez, PHH, Zhang, G., Schnaar, RL., Sheikh, KA. Structural requirements of anti-GD1a antibodies determines their target specificity. Journal of the Peripheral Nervous System. 2005; 10; Supplement 1: 54.
• Lehmann, HC, Lopez, PHH, Nguyen, T., Zhang, G., Kieseier, BC., Sheikh, KA. Anti-GD1a antibodies impair neurite outgrowth in an in vitro model of nerve regeneration. Journal of the Peripheral Nervous System. 2005; 10; Supplement 1: 51-52
• David, MA., Spies, JM., Pollard, JD., Zhang, G., Armati, P., Sheikh, K.A. Intraneural injections of anti-ganglioside antibodies induce reversible conduction failure. Journal of the Peripheral Nervous System. 2005; 10; Supplement 1: 18-19.
• Zhang, G., Lopez, P.H., Sheikh, K. A. Comparison of different brands of IVIg in an in vitro model of immune neuropathy. Journal of Neuroimmunology. 2006 Apr; 173(1-2):200-203.
• Lehmann, H. C., Lopez, P.H.H., Zhang, G., Ngyuen, T., Zhang, J., Kiesier, B.C., Mori, S., Sheikh, K.A. Passive immunization with anti-ganglioside antibodies directly inhibits axon regeneration in an animal model. Journal of Neuroscience. 2007 Jan 3; 27(1):27-34.
• Buchwald, B., Zhang, G., Vogt-Eisele, A. K., Zhang, W., Ahangari, R., Griffin, J. W., Hatt, H., Toyka, K. V., and Sheikh, K. A. Anti-ganglioside antibodies alter presynaptic release and calcium influx. Neurobiology of Disease. 2007 Oct; 28(1):113-121.
• Lopez, P.H., Zhang, G., Bianchet, M.A., Schnaar, R.L., Sheikh, K.A. Structural requirements of anti-GD1a antibodies determine their target specificity. Brain (In press).
• Zhang, G., Lehmann, H. C., Sheikh, K.A. Anti-GD1a antibody-mediated inhibition of neurite outgrowth and its reversal with erythropoietin. Journal of the Peripheral Nervous System. 2007; 12; S1: 96.
• Lopez, PHH., Zhang, G., Sheikh, K.A. Passive transfer of anti-GM1 antibodies from a GBS patient inhibits nerve regeneration in mice. Journal of the Peripheral Nervous System. 2007. 2007; 12; S1: 54.
• Lehmann, H. C., Lopez, P.H.H., Zhang, G., Ngyuen, T., Zhang, J., Kiesier, B.C., Mori, S., Sheikh, K.A. Inhibition of peripheral nerve regeneration via GD1a ganglioside. Journal of the Peripheral Nervous System. 2007; 12; S1: 51.
• Zhang, J., Zhang, G., Mori, S., Sheikh, K.A. Diffusion tensor imaging in detection of muscle degeneration in a mouse model of ALS. Annual Meeting of International Society of Magnetic Resonance in Medicine. Berlin, Germany, 2007.
• Zhang, J., Zhang, G., Mori, S., Sheikh, K.A. Quantitative Characterization of Mouse Calf Muscle Degeneration after Left Sciatic Nerve Axotomy with Magnetic Resonance Imaging. Annual Meeting of International Society of Magnetic Resonance in Medicine. Seattle, 2006.
• Susuki, K., Yuki, N., Schafer, DP., Hirata, K., Zhang, G., Funakoshi, K., Rasband, MN. Dysfunction of nodes of Ranvier: A mechanism for anti-ganglioside antibody-mediated neuropathies. Exp Neurol. 2012 Jan; 233 (1): 534-42. Epub 2011 Dec 8.
• Zhang, G., Lehmann, HC., Bogdanova, N., Gao, T., Zhang, J., Sheikh, KA. Erythropoietin Enhances Nerve Repair in Anti-ganglioside Antibody-Mediated Models of Immune Neuropathy. PLoS One. 2011; 6(10):e27067. Epub 2011 Oct 28.
• Zhang, G., Lehmann, C., Manoharan, S., Hashmi, M., Shim, S., Ming, G., Schnaar, RL., Lopez, PH., Bogdanova, N., Sheikh, KA. Anti-Ganglioside Antibody-Mediated Activation of RhoA Induces Inhibition of Neurite Outgrowth. Journal of Neuroscience. 2011 Feb 2; 31(5): 1664-75.