John P. Hagan, Ph.D.

Assistant Professor, The Vivian L. Smith Department of Neurosurgery

Contact Information
Telephone 713.500.6137

Education & Training

Research Interests

My research focuses on understanding the role of microRNAs and their post-transcriptional regulators in developmental and cancer biology. We and others have shown that microRNA expression is dysregulated in cancer and demonstrated using mouse models a direct role for these non-coding, regulatory RNAs in cancer initiation, progression, and metastasis. In addition, we are continuing our research efforts to delineate the importance of 3’ RNA polyuridylation in gene regulation, as we have recently described a Terminal Uridylyl Transferase (TUTase) named Zcchc11 that works with Lin28A to block biogenesis of the tumor suppressor let-7 microRNA family. My cancer studies focus primarily on types characterized by Lin28A/Lin28B overexpression and let-7 loss such as medulloblastoma, neuroblastoma, atypical teratoid rhabdoid tumors, and breast adenocarcinoma. Efforts are ongoing to screen for modifiers of the Lin28/let-7 pathway that may hold therapeutic potential in cancer and type 2 diabetes.

Selected Bibliography