Ying Xia, M.D., Ph.D.

Professor, Vice Chair (Research)
The Vivian L. Smith Department of Neurosurgery

Contact Information
Telephone 713.500.6288
Fax number 713.500.7787
Visit my research page

Education & Training

Selected Bibliography (since 2005)

  1. Chen F, Qi ZF, Luo YM, Hinchliffe T, Ding GH, Xia Y*, Ji XM*. Non-pharmaceutical therapies for stroke: Mechanisms and clinical implications. Progress in Neurobiology, in press, 2014. *Corresponding authors (Invited Review)
  2. Cao S, Chao DM, Zhou HH, Xia Y. A novel mechanism for cytoprotection against hypoxic injury: DOR-mediated Nrf2 translocation. Submitted.
  3. Kim JH, Kim SH, Song SY, Kim WS, Song SU, Yi TG, Jeon MS, Chung HM, Xia Y, Sung JH. Hypoxia induces adipocyte differentiation of adipose-derived stem cells by triggering reactive oxygen species generation. in press, 2013.
  4. Wang QY, Chao DM, Xia Y. δ-opioid receptors and inflammatory cytokines in hypoxia: Differential regulation between neuron-like and glial cells. Translational Stroke Research, in revision.
  5. Chen T, Li J, Chao DM, Sandhu HK, Liao XP, Zhao JL, Wen GQ, Xia Y. δ-Opioid receptor activation reduces ɑ-synuclein overexpression and oligomer formation induced by MPP+ and/or hypoxia. Exp Neurology, in press.
  6. Fenoy AJ, Goetz L, Chabardès S, Xia Y. Deep Brain Stimulation: Are Astrocytes a Key Driver Behind the Scene? CNS Neurosci Ther, in press.
  7. Jiang B, Shen RF, Bi J, Tian XS, Hinchliffe T, Xia Y. Catalpol: A Potential Therapeutic for Neurodegenerative Diseases. Curr Med Chem, in press. (Invited Review)
  8. Yang YL, Sandhu HK, Zhi F, Hua F, Wu M, Xia Y. MicroRNAs and hypoxic/ ischemic injury. Curr Med Chem, in press. (Invited Review)
  9. Tian XS, Hua F, Sandhu HK, Chao DM, Balboni G, Salvadori S, He XZ, Xia Y. Effect of δ-Opioid Receptor Activation on BDNF-TrkB vs. TNF-α in the Mouse Cortex Exposed to Prolonged Hypoxia. Int J Mol Sci 14: 15959-15976, 2013.
  10. Cao J, Wang SH, Ren YL, Zhang YL, Cai J, Tu WJ, Shen HJ, Dong X, Xia Y. Interference control in 6–11 year-old children with and without ADHD: behavioral and ERP study. Int J Devl Neuroscience 31: 342–349, 2013.
  11. He XZ, Sandhu HK, Yang YL, Hua F, Belser N, Kim DH, Xia Y. Neuroprotection against hypoxia/ischemia: δ-opioid receptor-mediated cellular/molecular event. Cell Mol Life Sci, 70:2291-2303, 2013. (Invited Review)
  12. He XZ, Yang YL, Zhi F, Moore ML, Kang XZ, Chao DM, Wang R, Balboni G, Salvadori S, Kim DH, Xia Y. δ-Opioid receptor activation modified microRNA expression in the rat kidney under prolonged hypoxia. Plos One, 8(4):e61080, 2013.
  13. Liang JF, Sandhu HK, Chao DM, Kim DK, Xia Y. δ-Opioid receptors up-regulate excitatory amino acid transporters of astrocytes in the mouse brain. British J Pharmacology, in revision.
  14. Tian XS, Guo JC, Zhu M, Li Minwei, gencheng Wu, Xia Y. δ-opioid receptor activation rescues the functional TrkB receptor and protects the brain from ischemia-reperfusion injury in the rat. Plos one, 8(7): e69252, 2013.
  15. Chao DM, Xia Y. From Acupuncture to interaction between delta-opioid receptors and Na+ channels: A potential pathway to inhibit epileptic hyper-excitability. Evidence-Based Complementary and Alternative Medicine, Volume 2013, Article ID 216016, 16 pages, 2013.
  16. Zhou F, Guo JC, Cheng JS, Wu GC, Sun J, Xia Y. Electroacupuncture and brain protection against cerebral ischemia: Specific effects of acupoints. Evidence-Based Complementary and Alternative Medicine, Volume 2013, Article ID 804397, 14 pages, 2013.
  17. Zhou F, Guo JC, Cheng JS, Wu GC, Xia Y. Effect of electroacupuncture on rat ischemic brain injury: Importance of stimulation duration. Evidence-Based Complementary and Alternative Medicine, Volume 2013, Article ID 878521, 12 pages, 2013.
  18. Kang XZ, Shen XY, Xia Y. Electroacupuncture-induced attenuation of experimental epilepsy: A comparative evaluation of acupoints and stimulation parameters. Evidence-Based Complementary and Alternative Medicine, Volume 2012, Article ID 149612, 10 pages, 2012.
  19. Yang YL, Zhi F, He XZ, Moore ML, Kang XZ, Chao DM, Wang R, Kim DH, Xia Y. δ-Opioid receptor activation and microRNA expression of the rat cortex in hypoxia. Plos One, 7:e51524, 2012.
  20. Chao DM, He XZ, Yang YL, Bazzy-Asaad A, Lazarus LH, Balboni G, Kim DH, Xia Y. DOR activation inhibits anoxic/ischemic Na+ influx through Na+ channels via PKC mechanisms in the cortex. Exp Neurol, 236 :228-239, 2012.
  21. Ding GH, Liu RQ, Chao DM, Xia Y. Neuronal responses to hypoxic stress in mouse cognitive cortex, Circulation Research, 111: A338, 2012.
  22. Chao D, He X, Yang Y, Balboni G, Salvadori S, Dong KH, Xia Y. Hydrogen sulfide induced disruption of Na+ homeostasis in the cortex. Toxicol Sci. 128:198-208, 2012
  23. Xu YQ, Yan JQ, Zhou P, Li JJ, Gao HM, Xia Y*, Wang Q*. Neurotransmitter receptors and cognitive dysfunctions in Alzheimer's disease and Parkinson's disease. Progress in Neurobiology, 97: 1-13, 2012. *Corresponding authors
  24. Feng Y, He XZ, Yang YL, Chao DM, Lazarus LH, and Xia Y. Current research on opioid receptor function. Current Drug Targets, 13: 230-246, 2012.
  25. Liang JF, Xia Y. Acupuncture modulation of neural transmitters/modulators. In Xia et al (eds): Current Research in Acupuncture, Springer, New York, Heidelberg, Dordrecht, London, pp 1-36, 2012.
  26. Chao DM, Xia Y. Acupuncture treatment of epilepsy. In Xia et al (eds): Current Research in Acupuncture, Springer, New York, Heidelberg, Dordrecht, London, pp 129-214, 2012.
  27. Asakawa T, Xia Y. Acupuncture treatment for Parkinson’s disease. In Xia et al (eds): Current Research in Acupuncture, Springer, New York, Heidelberg, Dordrecht, London, pp 215-254, 2012.
  28. Asakawa T, Xia Y. Can acupuncture treat Alzheimer’s disease and other neurodegenerative disorders? In Xia et al (eds): Current Research in Acupuncture (Research Monograph), Springer, New York, Heidelberg, Dordrecht, London, pp 255-302, 2012.
  29. Asakawa T, Xia Y. Future research in acupuncture—Better design and analysis for novel and valid findings. In Xia et al (eds): Current Research in Acupuncture (Research Monograph), Springer, New York, Heidelberg, Dordrecht, London, pp 687-726, 2012.
  30. Kim JH, Song SY, Park SG, Song SU, Xia Y, Sung JH. Primary Involvement of NADPH Oxidase 4 in Hypoxia-Induced Generation of Reactive Oxygen Species in Adipose-Derived Stem Cells. Stem Cells Dev. 21: 2212-2221, 2012.
  31. Park SG, Kim JH, Xia Y, Sung JH. Generation of reactive oxygen species in adipose derived stem cells: Friend or Foe? Expert Opin Ther Targets, 15: 1297-1306, 2011.
  32. Kim JH, Park SH, Park SG, Choi JS, Xia Y, Sung JK. The Pivotal Role of Reactive Oxygen Species Generation in the Hypoxia-Induced Stimulation of Adipose-Derived Stem Cells. Stem Cell Dev, 20: 1753-1761, 2011.
  33. Qian H, Feng Y, He XZ, Yang YL, Sung JH, Xia Y. Effects of inhibitory amino acids on expression of GABAA and glycine receptor in hypoxic cortical neurons during development. Brain Research, 1425: 1-12, 2011.
  34. Zhou F, Guo JC, Cheng JS, Wu GC, Xia Y. Electroacupuncture increased cerebral blood flow and reduced ischemic brain injury: Dependence on stimulation intensity and frequency. Journal of Applied Physiology, 111:1877-1887, 2011
  35. Feng Y, He XZ, Yang YL, Chen JS, Yin KS, Xia Y. Effect of delta-opioid receptor over-expression on cortical expression of GABAA receptor a1-subunit in hypoxia, CJP, 54:118-123, 2011.
  36. Chao D, Xia Y. Ionic storm in hypoxic/ischemic stress: Can opioid receptors subside it? Progress in Neurobiology, 90: 439-470, 2010.
  37. Zhou F, Huang DK, Xia Y. Neuroanatomic basis of acupuncture points. In: Acupuncture Therapy for Neurological Diseases: A Neurobiological View, Springer-Tsinghua Press, Heidelberg, London, New York, Beijing, pp 32-80, 2010.
  38. Wen GQ, Yang YL, Lu Y, Xia Y. Acupuncture-induced activation of endogenous opioid system. In: Acupuncture Therapy for Neurological Diseases: A Neurobiological View, Springer-Tsinghua Press, Heidelberg, London, New York, Beijing, pp 104-119, 2010.
  39. Wen GQ, He XZ, Lu Y, Xia Y. Effect of acupuncture on neurotransmitters/modulators. In: Acupuncture Therapy for Neurological Diseases: A Neurobiological View. Springer-Tsinghua Press, Heidelberg, London, New York, Beijing, pp 120-142, 2010.
  40. Guo JC, Cheng JS, Xia Y. Acupuncture therapy for stroke. In: Acupuncture Therapy for Neurological Diseases: A Neurobiological View, Springer-Tsinghua Press, Heidelberg, London, New York, Beijing, pp 226-262, 2010.
  41. Kang XZ, Xia Y. Effects of Acupuncture on Arrhythmia and Other Cardiac Diseases. In: Acupuncture Therapy for Neurological Diseases: A Neurobiological View, Springer-Tsinghua Press, Heidelberg, London, New York, Beijing, pp 263-288, 2010.
  42. Kang XZ, Xia Y. Acupuncture therapy for hypertension and hypotension. In: Acupuncture Therapy for Neurological Diseases: A Neurobiological View, Springer-Tsinghua Press, Heidelberg, London, New York, Beijing, pp 289-325, 2010.
  43. Shi D, He XZ, Xu HY, Xia Y. Research development of renal ischemia reperfusion injury and its protective strategies. Medical Recapitulate, 15:2802–2805, 2009.
  44. Kang XZ, Chao DM, Gu QB, Ding GH, Wang YW, Balboni G, Lazarus LH, and Xia Y. Delta-opioid receptor activation decreases anoxic Na+ influx and K+ leakage via sodium channel regulation. Cell Mol Life Sci, 66: 3505-3516, 2009.
  45. Yang YL, Xia XW, Zhang Y, Wang Q, Li L, Luo GH, Xia Y. Delta-opioid receptor activation attenuates oxidative injury in the ischemic rat brain. BMC Biology, 7: 55, 2009.
  46. Chao DM, Balboni G, Lazarus LH, Salvadori S, Xia Y. Na+ mechanism of delta-opioid receptor induced protection from anoxic K+ leakage in the cortex. Cell Mol Life Sci, 66:1105-1115, 2009.
  47. Feng Y, Chao D, He X, Yang Y, Kang X, Lazarus LH, Xia Y. A novel insight into neuroprotection against hypoxic/ischemic stress. Acta Physiol Sin, 61: 585-592, 2009.
  48. Lee EY, Xia Y, Kim WS, Kim MH, Kim TH, Kim KJ, Park BS, Sung JH. Hypoxia-enhanced wound-healing function of adipose-derived stem cells: increase in stem cell proliferation and up-regulation of VEGF and bFGF. Wound Repair Regen.17:540-547, 2009.
  49. Chao DM, Bazzy-Asaad A, Balboni G, Salvadori S, and Xia Y. Activation of DOR attenuates anoxic K+ derangement via inhibition of Na+ entry in mouse cortex. Cerebral Cortex, 18:2217-2227, 2008.
  50. Sung JH, Chao DM, Xia Y. Neuronal responses to hypoxia. In Ying W and Wang D (eds): “New Frontiers in Neurological Research,” Research Signpost, Kerala, pp 73–153, 2008.
  51. Malthankar-Phatak GH, Patel AB, Xia Y, Hong S, Chowdhury GM, Behar KL, Orina IA, Lai JC. Effects of continuous hypoxia on energy metabolism in cultured cerebro-cortical neurons. Brain Res. 1229:147–154, 2008.
  52. Tian XS, Zhou F, Yang R, Xia Y, Wu GC and Guo JC. Effects of intracerebroventricular injection of delta-opioid receptor agonist TAN-67 or antagonist naltrindole on acute cerebral ischemia in rats. Acta Physiol Sinica, 60:475–484, 2008.
  53. Tian XS, Zhou F, Yang R, Xia Y, Wu GC and Guo JC. Role of δ-opioid receptors in cumulative electro-acupuncture induced protection from ischemic injury in the rat brain. SH J TCM 42: 71–74, 2008.
  54. Tian XS, Zhou F, Yang R, Xia Y, Wu GC and Guo JC. Electro-acupuncture protects the brain against ischemic injury via up-regulation of delta-opioid receptors. J Chin Integr Med 6: 632–638, 2008.
  55. Kang XZ and Xia Y. Effect of electro-acupuncture on experimental epilepsy: Roles of different acupoints and stimulation parameters. J Acupunt Tuina Sci, 6: 279–280, 2008.
  56. Fadiel A, Eichenbaum KD, Xia Y. Cell interactome: Good neighbors or bad neighbors. Bioscience Hypotheses, 1: 255–257, 2008.
  57. Hong SS, Qian H, Zhao P, Bazzy-Asaad A, and Xia Y. Anisomycin protects cortical neurons from prolonged hypoxia with differential regulation of p38 and ERK. Brain Res 1149:76-86, 2007
  58. Xia Y, Zhou, F, Guo JC, Cheng JS, Wu GC. Optimal conditions for electro-acupuncture to protect the brain from experimental stroke. In “Scientific Approaches to Chinese Medicine,” Heidelberg School Edition, Heidelberg, pp 75–78, 2007.
  59. Xia Y, Zhou, F, Guo JC, Chao DM, Tian XS, Lu Y, Kang XZ, Cheng JS, Wu GC. Electro-acupuncture, delta-opioid receptors and brain protection from hypoxic/ischemic stress. In “Scientific Approaches to Chinese Medicine,” Heidelberg School Edition, Heidelberg, pp 79–82, 2007.
  60. Chao D, Donnelly D, Feng Y, Bazzy-Asaad A, Xia Y. Cortical delta-opioid receptors potentiate K+ homeostasis during anoxia and oxygen-glucose deprivation. J Cereb Blood Flow Metab, 27: 356-368, 2007.
  61. Chao DM, Bazzy-Asaad A, Gianfranco B, and Xia Y. Delta-, but not µ-, opioid receptor stabilizes K+ homeostasis by reducing Ca2+ influx in the cortex during acute hypoxia. J Cell Physiol, 212:60-67, 2007.
  62. Zhang J, Qian H, Zhao P, Hong SS, and Xia Y. Rapid hypoxia preconditioning protects cortical neurons from glutamate toxicity through delta-Opioid Receptor. Stroke, 37: 1094-1099, 2006.
  63. Chen Z, Fadiel A, and Xia Y. Functional duality of Merlin: A conundrum in proteome complexity. Med Hypotheses, 67: 1095-1098, 2006.
  64. Zhao P, Xue J, Gu XQ, Haddad GG, and Xia Y. Intermittent hypoxia modulates Na+ channel expression in developing mouse brain. Int J Dev Neurosci, 23: 327-333, 2005.
  65. Zhao P, Ma MC, Qian H, and Xia Y. Decreased Density of Delta-Opioid Receptors in Na+/H+ Exchanger 1 Null Mutant Mouse Brain with Epilepsy. Neurosci Res, 53: 442-446, 2005.
  66. Chen Z, Fadiel A, Naftolin F, Eichenbaum KD, and Xia Y. Circulation DNA: Biological implications for cancer metastasis and immunology. Med Hypotheses, 65: 956-961, 2005.
  67. Zhao P, Qian H and Xia Y. GABA and glycine are protective to mature and toxic to immature in cortical neurons under hypoxia. Eur J Neurosci, 22: 289-3000, 2005.
  68. Ma MC, Qian H, Ghassemi F, Zhao P, and Xia Y. Oxygen sensitive delta-opioid receptor-regulated survival and death signals: Novel insights into neuronal preconditioning and protection. J Biol Chem, 280: 16208-16218, 2005.

Research Monographs