Department of Pediatrics
Department of Pediatrics
The Department of Pediatrics

Faculty Biography

The Department of Pediatrics at the University of Texas Medical School at Houston is dedicated to improving the health and welfare of all infants, children, and adolescents.


Dr. Deborah L. Brown

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Education:

M.D.: University of Pennsylvania

Residency and Chief Residency: Children's Hospital of Pittsburgh

Fellowship: Children's Hospital of Philadelphia

Previous appointments: Children's Memorial Hospital, Northwestern University

Clinical and Research Interests:

  1. Coagulation disorders
  2. Thrombosis
  3. Anemia

Publications (selected):

  • Manco-Johnson, M.J., Abshire, T.C., Brown, D., Buchanan, G.R., Cohen, A.R., DiMichele, D., Hoots, W.K., Leissenger, C.A., McRedmond, K., Nugent, D.J., Shapiro, A.D., Thomas, G.A., Valentino, L.A., Riske, B.: Initial Results of a Randomized, Prospective Trial of Prophylaxis to Prevent Joint Disease in Young Children with Factor VIII (FVIII) Deficiency. Blood, 2005; 106(11):6a.
  • Tefs, K., Georgieva, M., Klammt, J., Allen, C.M., Aktas, K., Anlar, F.Y., Aydogdu, S.D., Brown, D., Ciftci, E., Contarini, P., Dempfle, C.-E., Dostalek, M., Eisert, S., Gökbuget, A., Günhan, Ö., Hidayat, A.A., Hügle, B., Isikoglu, M., Irkec, M, Joss, S.K., Klebe, S., Kneppo, C., Kurtulus, I., Mehta, R.P., Örnek, K., Schneppenheim, R., Seregard, S., Sweeney, E., Turtschi, S., Veres, G., Zeitler, P., Ziegler, M., and Schuster, V.: Molecular and clinical spectrum of type I plasminogen deficiency: a series of 50 patients. Blood. 2006, 108(9), 3021-3026.
  • Zhang, M., Rosenberg, P.S., Brown, D.L., Preiss, L., Konkle, B.A., Eyster, M.E., Goedert, J.J.: Correlates of spontaneous clearance of hepatitis C virus among people with hemophilia. Blood. 2005 October 4, 107(3): 892-897.
  • Goedert, J.J., Brown, D.L., Hoots, K., Sherman, K.E.: Human immunodeficiency and hepatitis virus infections and their associated conditions and treatment among people with haemophilia. Haemophilia, 2004, 10, (Suppl. 4) 205-210.
  • Gruppo, R.A., Brown, D., Wilkes, M.M., and Navickis, R.J.: Increased breakthrough bleeding during prophylaxis with B-domain deleted factor VIII- a robust meta-analytic finding. Haemophilia, 2004, 10, 1-3.
  • Liem, R.I., O'Gormon, M., and Brown, D.L.: The effect of red cell exchange transfusion on plasma levels of inflammatory mediators in sickle cell patients with acute chest syndrome. American Journal of Hematology, 2004 May;76(1):19-25.
  • Lefkowitz, J.B., Weller, A., Nuss, R., Santiago-Borrero, P.J., Brown, D.L., and Ortiz, I.R.: A common mutation, Arg457?Gln links prothrombin deficiencies in the Puerto Rican population. Journal of Thrombosis & Hemostasis, 2003; Nov;1(11):2381-8.
  • Brown, J.B., Emerick, K.M., Brown, D.L., Whitington, P.F., and Alonso, E.M.: Recombinant factor VIIa improves coagulopathy due to liver failure. Journal of Pediatric Gastroenterology & Nutrition, 37(3): 268-272, 2003.
  • Gruppo, G.A., Brown, D., Wilkes, M.M. and Navickes, R.J.: Comparative effectiveness of full-length and B-domain deleted factor VIII for prophylaxis- a meta-analysis. Haemophilia, 2003, 9, 251-260.
  • Abkowitz, J.L., Schaison, G., Boulad, F., Brown, D.L., Buchanan, G., Johnson, C.A., Murray, J.C., Sack, J., Sabo, K.: Response of Diamond-Blackfan anemia to metoclopramide: Evidence for a role for prolactin in erythropoiesis. Blood, 2002;100, 2687-2691.
  • Kulkarni, R., Aledort, L.M., Berntorp, E., Brackman, H., Brown, D., Cohen, A., Ewing, N., Gringeri, A., Gruppo, R., Hoots, K., Leissenger, C., Peerlinck, K., Poon, M., and Wong, W.: Therapeutic choices for patients with hemphilia and high-titer inhibitors. American Journal of Hematology 67:240-246, 2001.
  • Indo, Y., Mardy, S., Miura, Y., Moosa, A., Ismail, E., Toscano, E., Andria, G., Pavone, V., Brown, D., Brooks, A., Endo, F., and Matsuda, I.: Congenital insensitivity to pain with anhidrosis (CIPA): novel mutations of the TRKA (NTRK1) gene encoding the receptor tyrosine kinase for nerve growth factor, a putative uniparental disomy and a linkage of the mutant TRKA and PKLR genes in a family with CIPA and pyruvate kinase deficiency, Human Mutation, 18:308-318, 2001.
  • Shaw, P.H., Mancini, A.J., McConnell, J.P., Brown, D., and Kletzel, M.: Treatment of congenital erythropoietic porphyria in children by allogeneic stem cell transplantation: a case report and review of the literature. Bone Marrow Transplantation 27, 101-5, 2001.
  • Shaw, P.H., Brown, D., and Shulman, S.: Tuberculosis-associated hemophagocytic syndrome in an infant. Pediatrics Infectious Disease Journal Vol. 19, No. 5, May 2000.
  • Basani, R.B., French, D.L., Vilaire, G.I., Brown, D.L., Chen, F., Coller, B.S., Gartner, T.K., Bennett, J.S., and Poncz, M.: A naturally-occuring mutation near the amino terminus of IIb defines a new region involved in ligand binding to IIb/ 3. Blood 95(1), 2000.
  • Basani, R.B, Brown, D.L., Vilaire, G., Bennett, J.S., Poncz, M. : A Leu117 to Trp mutation within the RGD-peptide crosslinking region of 3 results in Glanzmann Thrombasthenia by preventing IIb/ 3 export to the platelet surface. Blood, 90 (8), 3082-3088, 1997.
  • Gruppo, R.A., Brown, D., Wilkes, M.M., and Navickis, R.J.: Meta-Analysis of Observational Studies of Full-Length and B-Domain Deleted Factor VIII for Prophylaxis- A Standard Statistical Approach. Haemophilia 9, 2003, 9 (6): 746-747.

 

Faculty Biography

Dr. Deborah L. Brown
  • Dr. Deborah L. Brown
    Assistant Professor
  • Department of Pediatrics
    Division of Hematology-Oncology
  • University of Texas-Houston Medical School
    6431 Fannin Street, MSB 3.020
    Houston, Texas 77030
  • phone: (713) 500-8360
    fax: (713) 500-8364
    e-mail: deborah.brown@ uth.tmc.edu
  • Gulf States Hemophilia and Thrombophilia Center
    6655 Travis St. Suite #400
    Houston, Texas 77030
Click for my PubMed publications