Faculty Biography

Michael E. Fant, MD, PhD

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Education:

SB, Life Sciences: Massachusetts Institute of Technology, Cambridge, MA

PhD, Biochemistry: Vanderbilt University, Nashville, TN

Postdoctoral Research: Massachusetts Institute of Technology, Cambridge, MA

MD: Vanderbilt University, Nashville, TN

Pediatrics Residency: Children's Hospital, Boston, NA

Joint Program in Neonatology : Harvard Medical School, Boston, MA

Certification:

American Board of Pediatrics, 1989

ABP Sub-Board, Neonatal-Perinatal Medicine, Re-certified 1998, 2002

Publications (selected):

• Peer Reviewed Manuscripts

• Fant ME, Harbison RD. Syncytiotrophoblast membrane vesicles: a potential model for examining the human placental cholinergic system. Teratology 1981; 24:187-99.
• Fant ME, Munro HN, Moses AC. An autocrine/paracrine role for insulin-like growth factors in the regulation of human placental growth. J Clin Endocrinol Metab 1986; 63:499.
• Fant ME. The in vitro growth rate of placental fibroblasts is developmentally regulated. J Clin Invest 1991; 88:1697-1702.
• Rogers J, Wiltrout L, Nanu L, Fant ME. Developmentally regulated expression of IGF binding protein-3 (IGFBP-3) in human placental fibroblasts: Effect of exogenous IGFBP-3 on IGF-1 action. Regulatory Peptides 1996; 61:189-196.
• Osorio M, Torres J, Moya F, Pezzullo J, Salafia C, Baxter R, Schwander J, Fant M. Insulin-like growth factors (IGFs) and IGF binding proteins-1, -2, and -3 in newborn serum: relationships to fetoplacental growth at term. Early Human Development 1996, 46:15-26.
• Fang J, Furesz T, Laurent R, Smith CH, Fant ME. Spatial polarization of IGF receptors on the syncytiotrophoblast cell membrane. Pediatric Research, 1997, 41: 258-265.
• Fant M, Weisoly DL, Cocchia M, Huber R, Khan S, Lunt T, Schlessinger D. Plac1, a trophoblast-specific gene, is expressed throughout pregnancy in the human placenta and modulated by keratinocyte growth factor (KGF). Molecular Reproduction and Development, 2002, 4:430-436.
• Eltayab Massabbal, Shanaz Parveen , D.L. Weisoly, D. Michael Nelson, S.D. Smith, and Michael Fant., PLAC1 expression increases during trophoblast differentiation: Evidence for regulatory interactions with the fibroblast growth factor-7 (FGF-7) axis, Mol. Reprod. Dev., 2005, 71:299-304.
• Md. Badiul Bhuiyan, Ferid Murad, Michael E. Fant The Placental Cholinergic System: Localization to the Cytotrophoblast and Modulation of Nitric Oxide. Cell Communication and Signaling, 2006. 4:4.
• J. Fang, D. Mao, C.H. Smith, M.E. Fant, IGF Regulation of Neutral Amino Acid Transport in the BeWo Choriocarcinoma Cell Line (b30 clone): Evidence for MAP kinase-dependent and MAP kinase-independent Mechanisms, 2006, Journal of Growth Hormone and IGF Research, 16:318-325.
• Fant ME, Barrera-Saldana H, Poindexter B, Bick R, and Dubinsky W. PLAC1 protein localizes to the apical region of the differentiated trophoblast and is associated with its apical, microvillous membrane surface, Mol. Reprod. Dev., 2006, In Press.

Invited Publications:

• Book Chapters:

• Harrison RW, Balasubramanian K, Fant, ME, Yeakley JM, Svec F, Fairfield S. Heterogeneity of AtT-20 cell glucocorticoid binding sites: evidence for a membrane receptor. IN: Steroid Hormone Receptor Systems, WW Leavitt, ED., Plenum Publishing Co., New York.
• Munro HN, Pilistine S, Fant ME. The placenta in nutrition. Ann Rev Nutrition 1983; 3:97.
• Fant ME, Cloherty JP. Temperature Control. IN: Manual of Neonatal Care. Cloherty JP, Stark AR, Eds., Little, Brown and Co., Boston, Revised Edition, 1991.
• Fant ME, Von Stockhausen H-B. The Postmature Infant. IN: Pediatric Therapy. Eichenwald HF, Stroder J, Eds., B.C. Decker, Inc., Philadelphia, 1993.
• Fant ME. Placental Growth Regulation: Lessons from the Mesenchyme. In: Local Systems in Reproduction. Naftolin F, Magness R (eds.), Serono Foundation Symposia, Raven Press, New York, 1993
• Fant ME. Placental Growth Factors. In: Placental Pharmacology, BV Rama Sastry, ed., C Press, Inc., 1996.
• Fant ME and Weisoly D. Insulin and Insulin-like Growth Factors: Implications for the Perinatal Period, 2001, Seminars in Perinatology, 25:426-35.

Location & Contact

6431 Fannin Street
MSB 3.020
Houston, Texas 77030
713-500-5757 (Voice)

Faculty Biography

• Michael E. Fant, MD, PhD
  Associate Professor
• Department of Pediatrics
  Division of Neonatal-Perinatal Medicine
• University of Texas-Houston Medical School
  6431 Fannin Street, MSB 3.242
  Houston, Texas 77030
• phone: (713) 500-5724
  fax: (713) 500-5794
  e-mail: Michael.E.Fant@ uth.tmc.edu
• Executive Assistant:
• Kim Self (713) 500-5727